| Entrez gene ID | | 1755 |
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| Official gene symbol | | DMBT1 |
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| Full name | | deleted in malignant brain tumors 1 |
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| Aliases | | ,FLJ61058,GP340,MGC164738,muclin, |
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| Gene summary | | Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq] |
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| Location | | Chromosome: 10 Locus: 10q26.13 |
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| Gene position | | 124320181 - 124403252 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 83072 bp |
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| Gene sequence |
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| OMIM ID | | 601969 |
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