Entrez gene ID | | 1769 |
Official gene symbol | | DNAH8 |
Full name | | dynein, axonemal, heavy chain 8 |
Aliases | | ,ATPase,FLJ25850,FLJ36115,FLJ36334,hdhc9, |
Gene summary | | Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Dynein heavy chains (DHCs) are responsible for force production and ATPase activity and contain a highly conserved catalytic domain with 4 P-loop consensus motifs involved in nucleotide binding. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. Axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH8 is an outer arm axonemal DHC (Chapelin et al., 1997 [PubMed 9256245]; Neesen et al., 1997 [PubMed 9373155]).[supplied by OMIM] |
Location | | Chromosome: 6 Locus: 6p21.31-p21.1 |
Gene position | | 38690552 - 38998567 Map Viewer |
Gene orientation | | plus |
Gene size | | 308016 bp |
Gene sequence |
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OMIM ID | | 603337 |
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