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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DNTT (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1791
Official gene symbolDNTT
Full namedeoxynucleotidyltransferase, terminal
Aliases,TDT,
Gene summaryThis gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q23-q24
Gene position98064085 - 98098321  Map Viewer
Gene orientationplus
Gene size34237 bp
Gene sequence
OMIM ID187410