Entrez gene ID | | 1800 |
Official gene symbol | | DPEP1 |
Full name | | dipeptidase 1 (renal) |
Aliases | | ,MBD1,MDP,RDP, |
Gene summary | | DPEP1 (EC 3.4.13.11) is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982 [PubMed 6122685]). DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984 [PubMed 6334084]). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990 [PubMed 2303490]).[supplied by OMIM] |
Location | | Chromosome: 16 Locus: 16q24.3 |
Gene position | | 89679716 - 89704839 Map Viewer |
Gene orientation | | plus |
Gene size | | 25124 bp |
Gene sequence |
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OMIM ID | | 179780 |
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