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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DPEP1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1800
Official gene symbolDPEP1
Full namedipeptidase 1 (renal)
Aliases,MBD1,MDP,RDP,
Gene summaryDPEP1 (EC 3.4.13.11) is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982 [PubMed 6122685]). DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984 [PubMed 6334084]). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990 [PubMed 2303490]).[supplied by OMIM]
LocationChromosome: 16   Locus: 16q24.3
Gene position89679716 - 89704839  Map Viewer
Gene orientationplus
Gene size25124 bp
Gene sequence
OMIM ID179780