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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DR1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1810
Official gene symbolDR1
Full namedown-regulator of transcription 1, TBP-binding (negative cofactor 2)
Aliases,NC2,NC2-BETA,
Gene summaryThis gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p22.1
Gene position93811478 - 93828149  Map Viewer
Gene orientationplus
Gene size16672 bp
Gene sequence
OMIM ID601482