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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DUSP1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1843 Official gene symbol DUSP1 Full name dual specificity phosphatase 1 Aliases ,CL100,HVH1,MKP-1,MKP1,PTPN10, Gene summary The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq] Location Chromosome: 5   Locus: 5q34 Gene position 172198203 - 172195093  Map Viewer Gene orientation minus Gene size 3111 bp Gene sequence >DUSP1:complement(17006366..17009476):Length=3111 TCGCTGCGAAGGACATTTGGGCTGTGTGTGCGACGCGGGTCGGAGGGGCAGTCGGGGGAA CCGCGAAGAAGCCGAGGAGCCCGGAGCCCCGCGTGACGCTCCTCTCTCAGTCCAAAAGCG GCTTTTGGTTCGGCGCAGAGAGACCCGGGGGTCTAGCTTTTCCTCGAAAAGCGCCGCCCT GCCCTTGGCCCCGAGAACAGACAAAGAGCACCGCAGGGCCGATCACGCTGGGGGCGCTGA GGCCGGCCATGGTCATGGAAGTGGGCACCCTGGACGCTGGAGGCCTGCGGGCGCTGCTGG GGGAGCGAGCGGCGCAATGCCTGCTGCTGGACTGCCGCTCCTTCTTCGCTTTCAACGCCG GCCACATCGCCGGCTCTGTCAACGTGCGCTTCAGCACCATCGTGCGGCGCCGGGCCAAGG GCGCCATGGGCCTGGAGCACATCGTGCCCAACGCCGAGCTCCGCGGCCGCCTGCTGGCCG GCGCCTACCACGCCGTGGTGTTGCTGGACGAGCGCAGCGCCGCCCTGGACGGCGCCAAGC GCGACGGCACCCTGGCCCTGGCGGCCGGCGCGCTCTGCCGCGAGGCGCGCGCCGCGCAAG TCTTCTTCCTCAAAGGTACGCCCTCGGGGAAGCTCGGGGCGGGCCGCACACCCCTGAGGT TTTGCCCGGTACCCCTGGCTCTCGGCTCCCGGGGGATCGCCCCACCTGCAGCGCGTGGGC GCTGGAGTACATTTATCTCTGGAACTTGTCATTGGCTTTGTTTGGCTCTGGAAACAAAGA CTTGCCTGGGCCTTTCCGATGTAAACTTCCAGCCCTTGGTGGGTGGGGGAGTTGTATGAA GGTGCCGTGTCCCGGTGTCACTAATGGGGAAAAAAAATGTCTTTGTATTCCCAGGAGGAT ACGAAGCGTTTTCGGCTTCCTGCCCGGAGCTGTGCAGCAAACAGTCGACCCCCATGGGGC TCAGCCTTCCCCTGAGTACTAGCGTCCCTGACAGCGCGGAATCTGGGTGCAGTTCCTGCA GTACCCCACTCTACGATCAGGTTAGTAGGTGTCCCTGCCACAGGGAAGAAGTAAGAACTG GCAAAGGCATGGAAGAGTAGTGCCAGGGAGAATATAGAAAGTGACCTGCAGCATTATTTA TAACGGAGGGGACACAGGGATATGATTTATTCCACAGTTAAGTGGTCTGACGGAGCCGAG TCTCCAATTGTAGGCTCTACGGAAATGAACTTGCTGGTCCTGCCCAGGCAAATGGGCTTA GTTCCCTATTTATTTATCCTCCAGCAACAGAACTGAGTTCACTCGGTATCTGAAATTGAC TTTTCCAGCAGAAAGTTTTTGTGGGTATGGGCACTGGCCTTGGCTTTGAGCAAGCTTGAT GAATGTTGGATATTTCTGGATTTCAGGGTGGCCCGGTGGAAATCCTGCCCTTTCTGTACC TGGGCAGTGCGTATCACGCTTCCCGCAAGGACATGCTGGATGCCTTGGGCATCACTGCCT TGATCAACGTCTCAGCCAATTGTCCCAACCATTTTGAGGGTCACTACCAGTACAAGAGCA TCCCTGTGGAGGACAACCACAAGGCAGACATCAGCTCCTGGTTCAACGAGGCCATTGACT TCATAGGTAAATGGAATGGATGCCTGGGGCTTTTCTGCCTTTCTCTTCTCATTTTAGCCA CTAAGCCCAACCTCTGTGGCAAGAGCTTGAAGTTTTCTGAGCCTTCTTCCACACATTCAG TATCAGTCTGGTGTGGGCAACATTCCTGTAAAATATGAATTTGATTCGATGTCCCACTTT ACAGATTTGCAAAGTGGGGCTCACAAAGTTGAATTGACTGGTCTGAGATCTATCTGCTAA GTGGAAATCCCCAGTCTGAGTTTAAATCCTGTGCCATCCTTTGCACAGTGCCCACGTTGC CTCCATGAACAGTATCCATGTGATGGCATGTGGTGATGTTGACCATTTCTAGACAAGACA CACATGACCTTTCTCAGATACACTGTACCTGGGCTTGGGGTGGTTCTCCTGAACTCTCAA GTAACCAGCCGCTCCTTTGGTTTTCCAGACTCCATCAAGAATGCTGGAGGAAGGGTGTTT GTCCACTGCCAGGCAGGCATTTCCCGGTCAGCCACCATCTGCCTTGCTTACCTTATGAGG ACTAATCGAGTCAAGCTGGACGAGGCCTTTGAGTTTGTGAAGCAGAGGCGAAGCATCATC TCTCCCAACTTCAGCTTCATGGGCCAGCTGCTGCAGTTTGAGTCCCAGGTGCTGGCTCCG CACTGTTCGGCAGAGGCTGGGAGCCCCGCCATGGCTGTGCTCGACCGAGGCACCTCCACC ACCACCGTGTTCAACTTCCCCGTCTCCATCCCTGTCCACTCCACGAACAGTGCGCTGAGC TACCTTCAGAGCCCCATTACGACCTCTCCCAGCTGCTGAAAGGCCACGGGAGGTGAGGCT CTTCACATCCCATTGGGACTCCATGCTCCTTGAGAGGAGAAATGCAATAACTCTGGGAGG GGCTCGAGAGGGCTGGTCCTTATTTATTTAACTTCACCCGAGTTCCTCTGGGTTTCTAAG CAGTTATGGTGATGACTTAGCGTCAAGACATTTGCTGAACTCAGCACATTCGGGACCAAT ATATAGTGGGTACATCAAGTCCATCTGACAAAATGGGGCAGAAGAGAAAGGACTCAGTGT GTGATCCGGTTTCTTTTTGCTCGCCCCTGTTTTTTGTAGAATCTCTTCATGCTTGACATA CCTACCAGTATTATTCCCGACGACACATATACATATGAGAATATACCTTATTTATTTTTG TGTAGGTGTCTGCCTTCACAAATGTCATTGTCTACTCCTAGAAGAACCAAATACCTCAAT TTTTGTTTTTGAGTACTGTACTATCCTGTAAATATATCTTAAGCAGGTTTGTTTTCAGCA CTGATGGAAAATACCAGTGTTGGGTTTTTTTTTAGTTGCCAACAGTTGTATGTTTGCTGA TTATTTATGACCTGAAATAATATATTTCTTCTTCTAAGAAGACATTTTGTTACATAAGGA TGACTTTTTTATACAATGGAATAAATTATGGCATTTCTATTGAAATTTCAA OMIM ID 600714