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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DUSP2 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1844 Official gene symbol DUSP2 Full name dual specificity phosphatase 2 Aliases ,PAC-1,PAC1, Gene summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq] Location Chromosome: 2   Locus: 2q11 Gene position 96811179 - 96808908  Map Viewer Gene orientation minus Gene size 2272 bp Gene sequence >DUSP2:complement(1482737..1485008):Length=2272 GGAGTCGACCGCTCGGGCAGCGCCACCGCCACGAGAGCCCGGGACGCGGGAAAGACCGAA AGGAAGAGGAAGAGGCACCGGTGGCCATGGGGCTGGAGGCGGCGCGCGAGCTGGAGTGCG CGGCGCTGGGCACGCTGCTGCGGGATCCGCGGGAGGCGGAACGCACGCTGCTGCTGGACT GCCGCCCCTTCCTGGCCTTCTGCCGGCGCCACGTGCGCGCCGCGCGGCCAGTGCCTTGGA ACGCGCTGCTGCGGCGCCGCGCGCGCGGCCCTCCTGCCGCCGTTCTCGCCTGCCTGCTGC CCGACCGCGCGCTGCGGACGCGCCTGGTCCGCGGGGAGCTGGCGCGGGCCGTGGTGCTGG ACGAGGGCAGTGCCTCGGTGGCGGAGCTCCGGCCCGACAGCCCGGCTCATGTGCTGCTGG CCGCGCTGCTGCACGAGACCCGCGCGGGGCCCACTGCCGTGTACTTCCTGCGAGGTGAGC AAGCCGGCCGCCCTTGGCCCGCCCCACCCGACTCCAGCCCGGCTTTCCCTGCTGATCGTG CTCTTCCCCTCCTTGCAGGAGGCTTCGACGGCTTCCAGGGCTGCTGTCCCGATCTGTGCT CTGAGGCCCCCGCCCCTGCGCTGCCGCCAACAGGGGACAAAACCAGCCGCTCCGACTCCA GGGCTCCTGTCTACGACCAGGTGAGTATTGACCCCCCTCCCCCGAACCTCCCTCTCTCCC CGCCGCGGACTGGGCGCCTCTAGGGAAAGAGCCTGCCATTTGGGGATGCGAGCAGTTTGC CCATATACACACACTTTTATACGTGTGTGTGTTGGGGGAGGGGGTGGGGCATGGCTGCTC GCGCGTGCCTGTATGGGTCTGTGTATGTTTGCATGTGTATGTTGGGAGCATGAAGGGAAA TGTATGTCCCGGTGTGTCCTCCGCACATTCCTGAGACCTGTCTCAGGTCAGGAGGACTGG CTGAGGAGTCCTCTTGTCTCGGCCAGCCCATGGGGTCTCCACCCGCTGCTGCTCCAGCTC TCCGGGGCTGGGCTGGAAAGGCCTCACCGCCCCTCTGTTCCCTCCAGGGTGGCCCTGTGG AGATCTTGCCCTACCTGTTCCTGGGCAGCTGCAGTCACTCGTCAGACCTGCAGGGGCTGC AGGCCTGTGGCATCACAGCCGTCCTCAACGTGTCCGCCAGCTGCCCCAACCACTTTGAGG GCCTTTTCCGCTACAAGAGTATCCCTGTGGAGGACAACCAGATGGTGGAGATCAGTGCCT GGTTCCAGGAGGCCATAGGCTTCATTGGTAAGGGGGCACCTCTGCCCAGAAATCCCGAGG GGCTCCAGAGGAGAGGACTGGGGGCACCTGTCTCCTGGGCTGTGCACATTCCGTCTGACA CCACTCCCCCATCTCCCTTGCAGACTGGGTGAAGAACAGCGGAGGCCGGGTGCTGGTGCA CTGCCAGGCGGGTATCTCGCGCTCTGCCACCATCTGTCTGGCATACCTCATGCAGAGTCG CCGTGTGCGGCTGGACGAGGCCTTTGACTTCGTTAAGCAGCGCCGGGGGGTCATCTCCCC CAACTTCAGTTTCATGGGGCAGCTGCTGCAGTTTGAGACCCAGGTGCTGTGTCACTGAGG TGGTGCCCCTCTGCCTGCCTGCCCCACTGTGCTGGCAGGAGCTGACTGTGGACTGGTGGG CTCCCCTCTGGGCCAGCACAGTCCCCTCACCTCTGGCAGGGCTGCTACCTCCTCAGAGTT TCAGAAGCCCCCACATGGGGGCTCTAGGAATGCCGGCATGCTGGTCTTTCCGACCTGGTG CTCTTCTGCTGGGGGACTGAGGCTGGCCCTCATTCGGGGTCGGGAACCAAGGGTGTGTCT GCTCTTTCCCTCCCCATCCTCTGGCAGAAATCAGCTAGACGCTATACCGTGGACTCTCCC TGGTCCACCACCATGTTGAAGCCCTTGGCAGCCTGAGAGCTCCAAGGAACAAGCTGTGAC AACCAGGAGCCCTGTCTGTGGGTTCGTCTGCCCAGGGCCTGGAGCCCAAGCCCTGTGTTC CTGGGGAAGCTGGGGACTTGGGAAGTGATGGGTGTGTCATGTTGCGTGTGTCTGTCTGTG AGCCTTTCACACCTGTGCTGGCGCTGGAAAATTATTTGTGCTCAGCTGACATTTAACACT CCCTCCCCCGCTTCCTCCTAGCCCTGTGGGCAGGGGTTGGAAACTTAGCACTTTATATTT ATACAGAACATTCAGGATATGTCAATAAAATATTGTTATATTTAAAAAACAA OMIM ID 603068