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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DUSP3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1845
Official gene symbolDUSP3
Full namedual specificity phosphatase 3
Aliases,VHR,
Gene summaryThe protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q21
Gene position41856368 - 41843489  Map Viewer
Gene orientationminus
Gene size12880 bp
Gene sequence
OMIM ID600183