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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DUSP5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1847
Official gene symbolDUSP5
Full namedual specificity phosphatase 5
Aliases,DUSP,HVH3,
Gene summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q25
Gene position112257625 - 112271302  Map Viewer
Gene orientationplus
Gene size13678 bp
Gene sequence
OMIM ID603069