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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DUSP8 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1850 Official gene symbol DUSP8 Full name dual specificity phosphatase 8 Aliases ,C11orf81,FLJ42476,FLJ42958,HB5,HVH-5,HVH8, Gene summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq] Location Chromosome: 11   Locus: 11p15.5 Gene position 1593150 - 1575281  Map Viewer Gene orientation minus Gene size 17870 bp Gene sequence >DUSP8:complement(1515281..1533150):Length=17870 CCGAGGCGAGCGCGAGCGAGGTGAGCGGAGGCGCCGGCGGGGCGGGGGCGGGCGCCGGGG ATGGGGTTCACCGGCCCGGGCCGGGGGGCGGAGGGCGCCGCGTCGGGGGCGCTGGGGCAG CGGCACCCGGTGGGCGCCCGGGAGGAGGAGGCGGCCCCGGAATGAGCGGCCACGGCCGTC CAGGACGCCAGGGACAGGGAGGCCCCTTCCCCGCCCCCCGCAACGCCCGGCGGACCCGGG CCCAGCCCACGCCCGCCCGCCGCGTTGCCGCCCTTCTCCCCGCAGCTCCTTCTTTGGGTG TGGAATGGGGGGGGGACAAAAATCCAGGACCCACCAGGGCCGCCTGAGATCCAGCGCGGA TCTGCGCGAGCCCCCGACGTCCCGAACGTCACCCCCGCGGGGGCCAGAACCGGAGCAGGC GGACCCTGGCCCGGAGTCGGTCCGGGAGGTGTGGAGCCTCGGCCGTGGGAGGGACGCGAC GGCCTCTGGCCTGGGACACCCGGGAAGGGGCCTTCCCCTGTCGGGGGGGAGGGCTGCAGA TCCATCCCCCCAGTGTCCAGGCCGCACTGCCTCCCCATCCCGGGGTGCCCAGCCGGCCCC TGAGGGATAAAGCCCCCGCGCCCTTCCGCCTGCTGCAGAGGCAGCCGCGGCGCTGGGGGA GGGGCTGGCACAGCCAGGCTGCTGCAGCCACCTCGCTAGGCCCAGCTGCCCAGCCTGGGA TGCGGAGCAGACCAGGTGGGGATACCTAATAGTCTGGCCTGGAGGGGAGGGGGCAACAAT AGGCCCAGCCCCAACAGGGTCACCCCTTCTGGGAGAATCTGCCTCCGTCTCCCTGCTGCG GGGTGTACCGGCCTCTGCTGAGGGGAATAGGGGCTCTGGTGCTGCAGTGATGGGGGGCGG GGACACTGTGGGATGGAGGAGGGGGTGGCAGGATGTAGCGTGGCTCCGCAGTGCTCTTGC TGTGCAGCTTGGGGTGGGGGTGGGGTGCTGCAGGCCAGGGAAGCTCCTTTTGTGCCCCAG CGGGGGGTCTGAGGGGAGATCCAAACCCCGGCACTCTCCCTTGCCTCCCTTCTGGCACAG CCCACCCAGAGACACTGTTGCACCTAGGGCGGTCCAGGGGTGAATGTAGCACCCCAGGCC CCAGCCCTCCACCAGGAGGACAGTCCCATGCATTCACTGCTAATAAGCACTGGATGCGGA TGGCAGATCATGTGACCCCAGCTGGAAGTTCATCCTGAAGTCTCGCTGAAATACCTCCTG CTGCAGCCAGCCGGGGGCTGCACGAGTGTGGCTGGGCAGGTTCTATTCCCCTGGTATCCT CTGTCCTCGGGGAGGCTTCTGGGAATAAAGTCCCATTAACAGAGGTGCAGAAAGACGCTT AGAGTCAGTCTCTGCTCCAGGACCCTTCTCTTCTCAGGCTGGGGCTGAAGTCAGGGCCTA GAGGCTGCCACTGGACAGGTGCCTCGAAGGGGCATCAGCTAGGGCCTGGGGAGACCTAGG TGTCACTTCTTGCAGAAGGCAGGGAAAGGGGCAGACCCACAGTGAGAGAGAGGTGGTTGG ACTCTGGCCATGAGAACTGCACCCGCTGAGGCCCCCTCTGCCGGAGTTGCTCAGGGCAGT GAACCTTGGAAGCGCCACACTGGTCCTGATGTTTAGCATGTGGCACAGTGACCAGGAGGA GGGACACAGGTCTGGTGGGAAGGGAGGGAACCTGGATATGTCCGGCTCTGAGACTCGACT GTCACGGCCCCTTGTGCCAAGTCCTCCCATCCCCTGCCCTGCCCGGACCCCGTTCCTGGG ATCGGAGGGAGCCCCCCGCCCCACCCCACTTTCTCCCAGGTCCACAGCTTCCCCAGGCCA GCGGAGCAGAGTGTAGGCCAGCTTGGGTCCTACAGCACTAGCCAAGGGAGCTGAGGGGAG GCAGGGATGAGGGCATCTGGGGGAGCCCAGTGAGGGAAGATGAGCTGACCTGTGTGAGTG CAGGGTCCCTGCCTCCCAGAGTTGCCACCCACCAGTCTCTCCTCAGCCTCCTTAGTGTGA CGATTTCTGCCTCCAGAAGCATCCCTGGGTAACAGTGAGCCGGACAGCTCCAAGAGCCTG CCTAGGTGTGAGGGGGAGACACAGTCCCATCCCCCCATGCTTGACAGTCCTGGCAGCTGT CTCTGAAGGTAGTGAGTCCCCATTTCTAGGTGCTGAGCAGAAGGTAACATGGTAAGGATG CTGTCAGTTGAGAGCTGGGGGTGGCCTGGGACTCCCTGGTCCCGTCTGTGCTCAGGGACA GGAATGTGCTGCACAGAGACGCTGGGTGTGGGAGCTCGTGTTTGTAAGGAGTCTGAAGCT GACCCCTCGGGTACTGGAGTCCTGGGGTTCTCAGGGGATCCTGCATACAGAGGGCAAGGA CGTGCGTGTACTCTAGTGTATGTCCAGCCCACGCGTGTGCACATATTCACGCGTGGGTAC TTGCACACAGGGCAGGTGGATTGTGGGTAAGGAGCACCAGCCCTGTGTGTGGAGTGGGTG TGCAAAGAGGTGTGTTCTGGCACGCACAGAGGGCAGTGTGCACGCAGCACTGGAGCCAGG CGTGCTGTGTCCCAGGGGAGGGTGGCGGCCTGGTGCCTCCTGGAAGGTGTGGGCCTGGGA GGAGCCTTCTTCTGACTTTGGACTTGGAAACTGCTTCCTCCTGGGCTCAAAGACTTTTGA AAAGGGTGTATGGGGCTGTGCTAGGGGGCATCCTGTCCCCAGCCCTGCCTCTCACCCCCC AACCCCTAGGCACTGGAATAGCAGGGCCACAGGTACTCAGGAGGGCTTGGCATGTGGGGC CGTGAAAGGAGAGGCATGGAACCAACACCATCCACATTTCCTTACCTCTGTTCCCACATG GCCAGTGCTGGCCCCACTGATCTGCACCAGACTGTCCTTAGTGTCTCTGCTCCCCACCCC ACCCAACCTGCCCCATCCCTGGCATAGCTGAGCCCCGATCCTTAGCATCTGGGGAGACAG AGGTGAGGAACATGTCCCCCTGGGAGCTGTAGGTCCAGGGAGACCCTGTGGGTGAGGATG CTCTCCCAGAGGCCAGCATGGCACAGAGGCTTCCTGCAGGAGGGGGCACTCGGCCAGCCC TTCGCAGTACAGAGAAGGCCTCTGAGGGGGCGGGGAGCCGGCGAGCTGCAGGGAGCATGC TGGGCACAGCAGGTACCTGGAGTGGGAAGGAAGGTTAGGACCAGGTAGGGCAGAGGAGCG GAGGGGCTGAGGACTGGGCTCTGCACTGCCGGGCACCTGCTGGGGTGGGTAGGAGAGAGC AGGGAGGGGCGCGTGCCCACTCTGCAGAGGAGCCTGCTCCATGGTGGTGGCTGCCGCAGG AGCAGCGGTTGCCTGGCACCTCTGCTGTTGCCATGGTGACGATGGAGGTGCTAACTTGCT AATGAATCCCCTTCGGCTGCAAATAACAATACTATTGTGGGTGATAGGCCCAGCTCCAGC TCAGCGTTGCTTAGGAGGCAGAGCAGGGCCAGGTAAAGGCCAGGACCCGTCCTCCCGCCC CTCCAGCCCCTGCCCACCACCCTGCAGCTGGACTTGCCCTCCTCCCTCCCCTCCCTCTGG GTCTCAGATCTGGCTGGCTGCACCGAGGTCTCTCATGGCAGTGTCAGGACTCAGGGCTGC ATGAAGGCTAGGCCCTGGCTGCAGAGAGGGCGAGGGCCTCTCCTCACACCTGCCCTCCTC CCTGCACTGGGGGGTATTTGCTTCTGTTGTTTTCAGTGAGAGAGAATCCACCCCCACTTA ACGGATGAGGACATTGAGGCCGGGGCAGCTCCTCAAAAGACCCCCAGCCCAAGTGTCCCT GCCACTGCAGCCTTCTCGGGGTTCTGGGTCTCTGAGCTGGACCCTTGGGTATCCTACGGG GCACCTGGAGCCGCTGTCTCACCAGAACCACACATCTGGGCCCTCGCCTCTCACCACCTG TGCAAGGCTCAGGTAGAACTCGGGAAGGACAAACAGCTCATCAAGGACCCCCTGTGGGTA GTCAGGGACCCCCTTGGCAGGCAGAGACCCTCCACAGCAGGCAGGCAGCAGGCCCTTTTG CTGTTGAACTTGCTGGGTCTGGCCCTGGAGAGGACTCCCAGGCCTCGTTCCCCACCCTGT GGTGGAGGCTGGAGCACCAGCCCAGGAACGTTATCTGAGTGGGATCCTGAGGCCCTGCTG ACCAGGTGCCACTGCAATCCCTGGTGTCAGCCGTGGGGTCAGCTGAGGCTGCCCATCCAC AGTCAGGTGTTTCCCTGGCCTCTGGCAACAGGAGGGATGGTGGGAATGCACAGAAGCCTG GGCCCAGTCGAGGCGGGAGGGGCCAGGCAGGGGCCAAGCTTGAAGTGTCTGGAGAAGGAG AGTGAGTGCGAGGCTGGGGCTCCTGGGCAGGGAGGAGCTGGGACCTGCCCCTCAGTGTGG AGTTGGGGCTGGGCCAGGGACGAGGTCCACACCAGCCTTGCACCTGCTGCTCTGTGAACT CTCTCACTGGCCCCCGCCGGCCTGGGAGCTGACCTGGAGAGTCCAGAAACGGTGGTGGCC TCTGTCCCCAGCCTGCTGTTTGCAGTGCATGGGTGTCCTCAGGGCGCCTCCCCCCAGTGC CTCCTGTGGCTGTGGGTTGGGGGTCTGGCTTGCTGAGGGCCCGCTACCCACCGTAGCCCG CTTTGCACAGGGCGCAGGGCCCAGGGTACATCTATCTCCCAGCCTTCCCTCAGTCCTGAG CTGGGTGGAGTAAACTTCCTGACTGCCTGGCAGCTGTGGGGGCACAGGGAAGATGGCATT GCAGGGACACCCAGTGCCCATCTGTGTGTGACCCAGGTGTGACCCAGGTCCCAACCCTGC CCCAAGCCTCGGTTTCCCCATAGTTAAAGCAAACTCATCATCCTTAACACTATGCGCCTC CTAGGGGCTGTGAGTGTAAAGTGGACCCAGAGGAAGGCCAGTCCTGGCAGGTGACAGGGA GATGGGGCCCGGCAGTGGGGCAGTGACAGGCTTGTCATCAAGCCTGCAGGAGGGGCTTCC GGAGACTCCATCCTCAGACATCCCTACTCCACCTGCCCACCCGGCAGTCTGAGGCCTTTG CAGGCCATGCCGAGGGCCTGGCACCTGCGGGGTCCCCGACACTGACCCTCCTCCCAGGGC TGCCCCGCCCCTCCCATCCTGGGCCCTATCAGCCCATGAAGGAGCCTCCTAGACCCCAGG CTCCGCTAGGGGAGAGGCACTGTGTGGGTGCAACACGCCCCTGCAGGAGCTGGGCACTCA CCCCCAGCAGGCACGTGGCGCACACTAAACCTCAGCCTGCAGGTCAGGAGGGCAGCAGTG GCAAAGGAGCCGTGCCTCTGTGCCTGAGCCCCTCCCGCACCCGCCTGCTATCCGGCTGCC CCCGGGAGCCCACTCTCCAGTGGAGGCAGCCCCAAGGCCACCATCCACCAGGGGCTGGAT TATCGGCTTACGGAGCTGCCCTGGAGTCAAGTCTCCAGGGATTGGACTCCCTGGGGCTGT GCTAGGGAGAGAGGGGCAGGTGTGAGGACAGCAAGCCCGGAGGAGGGCAGAGAGCTTGAC CATGTGGGAGGGTGAGGTGCAGTCCAGACCCCGACTTGCTGGGGGTCCTGTGGTGGAAAA GATGCAGAAGTCACAGCAGGGAGATGCCTGTGTCCCAGGGATGAGATGGAATGTTCTGGA ATGCCTAAGGGTCCGTGAACCCCAGGGCCCACAGGAAGGACCCCTGGCCTCTTCCAGCCC TCAGACCCTTCTCTGTGGGGCCCATTTGCCCCCCTCTGCCTTGTTGCATCCTGCTGAGAG CTGGCCTTGTGACCTGGACGGGGTCTCTCCAGAGGGAGAAGGGTTCCCACGGGCACATGT TGGTGTGTCCTGGTGGGCGCAGCTCCCAGCTCTGATCTGTCCTGGGGAGCTTCTGGGTGC CACCCAGGGGCCCGCAGCACTGCTGACCATCCCCCTGTCCCTGCAGGTCCAGCACCATGT GCTAGGTCACTCCCAGCGCGAGGCCACACCTGGGCCGTCGGAGCAGCCCCTCCTCACTTC AGGGGTCACCCTCCCCAGCACCCATTGCCCCACCATGGCTGGGGACCGGCTCCCGAGGAA GGTGATGGATGCCAAGAAGCTGGCCAGCCTGCTGCGGGGCGGGCCTGGGGGGCCGCTGGT CATCGACAGCCGCTCCTTCGTGGAGTACAACAGCTGGCATGTGCTCAGCTCCGTCAACAT CTGCTGCTCCAAGCTGGTGAAGCGGCGGCTGCAGCAGGGCAAGGTGACCATTGCGGAGCT CATCCAGCCGGCTGCACGCAGCCAGGTACCCAGCCCACTGCCCACCAGGCATGCATCACG TCCAGGGTCCACAGCTAAGGGGCCCTCAGCTCGGGCAGCACCCCCCTCCTCTGCCTTCCA GTCCAAACTCGACTCCTTGGGGTCACAGCCAGGGGCGTGTGGAGCAGTCCTCCCTGGCAC TTGCCTCTCACCGCTGCCTGTTGCCCCTGCTCAGGGCATCCCCCGCACCCCCGCCCGCAG CACCCTTCCCTACCCTCCCTCCAGGGCCTCCTTGCTCAGCTTCTGCACAGAGGTGCCGGG CCCTCCCCACGCAGATAGGACTGTGTGGCCAGGGCCAACCCAGGCTCACAGAGGGGAGCA GTGAGTGGAATAGCAAGGTGTGACCACATGGCAGTGGGAGCAGCCCAGCTGGCCTACACG GGACAGGGACAGCTGTGTGGTCCACTTCCACTGCTGTGAGGACAGGAGGGGTGGTCAAAA GGCACACGTGAGCAGTCCATGTCCCCGTCCCACAGCTTCCCCCAGCCCGCAGAGTATTCA GGGACCCAGAATTCTCTCTGTGGCCCCCCAGGAATGTCCTTCTGGGGAAGGACAGCTCAT TCTGCCCAGGACCATCAGGTGCAGCTGGGGAGGGACCAGCGGGGCTGTTGACCTGTGAAG GTGGCGGCACCTCCTCCTTCTACTGCCTCGCAGGGGACAAGGGTGACAAGCTCTTGGCCC TGGAGGCTTTGAGAGGGGTCTGGGTCACTGATAGGCCCTGTTCAGAGCTGGGACATGGGA GGACTCAAGTGGGATGGCCACTGGCCAGGAGTCCGCCCACCCCAAGGCCAGAATCGGCTC CCTTTGGTTTCCAACAAGGGGAATCTGGTGATTAATGACCCCCAGCAAGGACTCCCGGCA GAGTGCGATCCCATTGGCTGCCGGTGACGTCACCCAGCCCAGGGTTGGCGGCTCAGCTGG CTTAAGGGCTGAGTGTGTGCTTGCAGGGCGGGGGCACCGGTGCTGTCTGAGCAAAAGCCG CTCAACATCTGGGCTGGCCCTTGGGGTGGGGGAGGAGGGCAGGAGGAACCCAGCTTCCAG CTGCTGCCTCCGGAATTGGTGCAGGGGCCTGGGGTCCTGCTGCAGCCCTCTGTTTCTCCG CTGGGGGTTGGGGAGGGGATAGGGTGGGGAGCAGAATTGCTGGCTACACAGTTAGCCCCA CTGAGAGCCCACACCCGAAGGCATGCGTTTCAGGGCCGAGCTTCTCTGTCCCTCCGCCAC CCTGGGAGCCAGCCAGGTCCTATCCTGGGCTCCCATCGCACTCACCTGTGTCTCCTCCAC ACAGGCCTGGCCCAGAGCGTCCGTCCCCTTCACCCATGTGCATGGCATGGGGGCACAGCT GCGCAGGGCAGGAGTCCACCCCTCCCTGCCCCCATGGCTTGCTGTGTGGTGTGGGTGTGT GCATCTGGGCCTCTGGCAGATGGAGGAGAGTGTGTGACTGCACCTGCCCTCCCCTCCAGG CAGCAAGGTGACAGCTGCCTGCCTCCCATCATCTGATGCCCTTACTATTCCCTTGAGCCA GCATATCTGGGACGGGGCCAGGGCATCGATAGGTGGAGGCGGCATGCTGATCTCTGCCCC ATGGCCCCCAGGTGGAGGCTACGGAGCCACAGGACGTGGTGGTCTATGACCAGAGCACGC GGGACGCCAGCGTGCTGGCCGCAGACAGCTTCCTCTCCATCCTGCTGAGCAAGCTGGACG GCTGCTTCGACAGCGTGGCCATCCTCACTGGTGAGTCCATGACCCACGCCTCCCCGAGGC ACTTGCTCCGCCAGCAGTGGGGCTGGGGCTGGGGCTGGGGCATCAGGGAGGTGTCCGCTG GGCACGGGGGGATCTCCATACATCTGTGGTTCTTGAGGCCCCACCATCCTCTCCCCAGGA CGCCCACACTTCAGGACCCACCAATATGACTATCCTCAACACAGAAGGAAACCTCACAGT ACAGCTGGGCTCCAGAGGTGTAGGGCAAGGCATGCAGGCTGGGAGCCCCTCCCACTCCCG GAGCTCCTGTCAGAAGCCGGAGGCAGAGGCCCCATCCTCTGGAAACTCAGTTGGAGCCGT GGGGTCCCGAGGAAGTCCCCCCACCTCCGAAAGCCCAGCTGAGTGCAGGTTGCCTGGCAA CAGCCTGGCACCAAGGCTGCTGCCTGGGTCCCAGCAGACAGCCCCCAGGGATCCCTGTGG CCCAAAAGCAGCCTGGGCAACTGGCCCCAAGCCCTGGAGGCAGGGAAGCCGCCCCCCTAC ACACGCTGATACACACTCATATACACTCACACACTCGTGGTCCCAGAGGGTTCTTTCTTT CCTTGGGCTGTGGCTGAGGGCGTGTCTGTAGAATCCACCTCCTGGGGTCGGCCCAGGTCC CAGAGCCGGACGGAGCTGGCCTGTCCCAGGGATGTGCACCCTCCCCCATCCAGGTCTGGG GTCTTTGTCCAGGCTCCTTCTGCCTGGCCTCTGCTACCAGGGGCTGTTCCAGGCAAGCAG AGGATATGGGGGACTGTGGGGTGCAGGCACGGTGGGGTGAGGAGTAGGCAGCCAAGCCAG GCCCTTGGCCCTGCATCCAGTGGAAGCAGGGACCTTCACCCAGCCTGAGGGCGACTGTGG GGGATGAAGGGGTGGCAGCCGCTTTGGCCAGGCCGACCTCCCGACATGGCATGTCCTGGG ACCTAAAGGGCACCTGGGAGGCTTGAGGGTGGTCCAGTGTCCTGGGCAAGAGCATTGAGG CCAGGCTCCCTCCCCACCTCTCTGTGGGTGAGACCAGCACCCTGCACTGCTGGGTGGCCA TGGTCAGAGGGTGTCTGTGCGTCTGTGCATGGCTCTGGGCGTCTGGTGACCAGCATCTGC CTCTGCGAGTGTGTACGTGAGCATGTGTGTGCATGTATGTGTGTGTGTGCATGTGCATGC ATGTATGTGTGTGCATGTACATGTGTGCATGTATGGGCATATGCATGCCTGTGTGTGCGC ATATGTGCATGTACGTGTGTGCACGTGTATATGCATGTATATACATGGAGGTATATTTGT GTATGTACCCGCCTGTGCTTGTCTGGGTGAGATTTGGGATTTGTGTGCATATGTGTGAAC TCTCAGAACCAGAAGCCACAGAATGACGCACTCTGATCCAACCCTGTTCCCCTAGGTCCA GTTTGAGGACTGAACTGGTGGGGGGCGGGGAGAGAGTAGTTTGGGGCTTTTTACAGCTCA CCAGGTGTAACAGGACCCCTCCCAAAGGCCAGTTTGCTGCCCTAGCCAGGAATGGGAGTC AGGAGACTCTTCTTGGAGGCTGAGAAAGGTCCCAGAGTGGCACCTCCCTACCTGCAGGCA GATCCCAGGAAAGTCCCAAGCCTGGAAGGGCCTGTCTCCCTCGAGGCCAGAGTGGGACGG TTTGGGGGGCTGGGGCCCTCACCCAGCACTGGTGGGTGGGACAGCATGGGTGTGCAGGTG GGCGTGGATGAGTATGGGCATGGGAGGGGCCGGGCCTGTGCTAGGATTTGCCAGGAGGGC ACTCCCAGGGCCTGGTCATGCCACCCTCAGAACTGCCTTTCTGTGCTGACATCTGCCCTG CAAGGTTGAGGCTGTGTCCCCTTTTCTCCAGAAGTGCAGCTGCCAAGGAGTCCCAGGCCC CGTGGTATACAGTGGGCTCATGGCGACACCCAGGCAGGCCCACGGGCTCTGCCCTCAGGC TCCCTCCCACCCTGTGGTGGGCACAGCCCCTGCTCTGGGCTGGCTCTGCGAAGAACCAGG GAGAGTGGGAAAGAATATATTGGGGGGGGCAGGGGTGCTGCCCCTCACCCAGGAGAAGGG ATGTTCCAGGATCCCGCGGCACAGGCAACACAGCTCCTTGGTCCATTTGCAGGGACAGTA GAGGCCGGAATGTGAGGACCAAGCCTCTGTCCTCCCCACAGCAGGGCAGGTTTGCGGGAA GCGGGAGAGAAACAGTGGCAGGACAGGCTGTGCTGGGGTCCCAGGACTGCTGTGAAGCCC ACCTCCCCCTGCCGCTCCTCTTCCCCCACTCCAGCTGCGCTGCTCACGATGTTGGGGGGC AAGCGGCAAGGGATGAGAGAGGGGCCTGGCCCTTTAAGCAGCGGCCCGCAGTCGGCCTTG GACCCTTGGCCGGGCGACTGCACTGCAAGTGGGTGGGGTGGCGGCCCCCGCCCTGGCGGG GAGTCCAGGGGTCATGGAGGTGGCGGGCAGAAGTGCGTCTGTGACTGTGGCCATAAGCGC TTGCAGGGTCTCCCAGGTGGCATGGGGCAGGCACATGTCCTGGTACACACGCCTTTTTTC AAGTCTGGGATTTCACTGTGAGTAACAGGTGAACTGCAGGCGCTGCCCCAGAAACCCCCG AGTCAGGGAGCAGGGATACTGGGAAGGCGCCTTTGGAGATGCCTGGGGGTAGGGGTGCCT CCCCAGGGCCCAAAGAGTGCTGGGACCTACAAAGGGTCCACTGAACCCCAACACCCCTCA CTTATCACTCACCCCCAGAGCCTGGGTGGTTCTGAAATCCCTGGAGCCTCGGTCCCTGCT AGGCCTGGCATCCACAGTGGGGTGTGTAGGGACATCCACACTACCTGCTCCGCCTGGGGA GGTCCTGGGAAGCTTCCTGGGGAATTGCTGACATAGCTGTCGGTTCTCTGCACCTGTCCA GAGACTTTCCTGCCTTTACCTCCTCTGGGAGAGGTGGGAGGGTACTGATGGAATCCCCAG CACCTCCTCCTTTGGCCAGGCCCTGGAGAAAGCAGAGAGTAAGGCACAAAATCCCTGGGA GAGCCACAGGGAGGAGGAGAGGCAGCAGGTGGCAGAAGAGTCTGCAGAGAAGTGGTGCAG CCCTTCCGCCTCCCCGGGGCTGTCCTGCAGCGGGAACATCCAGGGCTACCCCAGCTCAGA ACAGTGAGTGGAAGCCAGCTACAGTGCCCATCCCAGCCTCTGCTCAGGGGAACCTGCAAG CTGGGGCGTCGTTGGTGACAAGTCACCTACCTGCTTTCCCCTGTCCAGTCAGCAGGTTCC CACAGAAGAGACTGTTCCTCCAAGGCTGCTGCCTCAACCCACCCAGCCTGGAGCTTCCCC TATCTCCACAGTCCCCCAGCGTCACGCCCTTTTTAGGGACACGGGGAGCTGGCACAGCAG GTGTTCTGGTTGGGGGTTTGCACACACTCCCCTGTCCTCAGGAGTTATCCAGGGTGGCTC TACTCCACCCAGCAGGGGAGAATGGAGAGAGGAGGAGCCCTAGGCACTGGGGGCACGCGG GGCAGGCAGTGGGCACCTGCTACACATGTGGCACCAGCCTCTTCTGCAAACCAGGACAAA AAAGAGCCCTGGGGTTCCCAGGCCCTGAGCTCCCGCCGTCACTCCCCTGCCCCGTCCAAT GGGATAGGGCAGGCCTCAGCCCAGCTGCCTCAGGCTCTGCACAAGCAGGAGCCGGCTTGC CATGGGGGCTTATGTTCTGGAAGGTGTCCTCGGGGTGGTGCTGGGCCATGCTGGCTTCAC CCTCCCAAGAGCTGGCAGCCACCAGGTGGGTGCTGCCCAGTTTCTGGTCCACATCGGTGG TCGCCCCAGCCAGGTCAGGGACGGCCAGGTCCATTCTCACCATGTGTCTTCGTGCTCATT ATCTTCTTGGAACCACATGATGCTGTGTGGCAGGCAGGAGGAGGAAGCTGAGACCAGAGC CATGGTGTGCACTACCCATGGTCACTGAGTCAGACATCCAGGGATTCACGTTCGGGTCCT TCCAGCTGGTGCAGGGCAGGGGACTTCCTCCCACCAGCCTGTGGCCTCGGACTTGGACGT GTGTGGAAGGCAGCAGCACACGCTGGTCACGTGTGCAGCGGGTGCCCACTGCCTGCTCTG CGTGCCCCCAGTGCCCCGGGCTTCTCCACTCTCCGTCCTCCCCTGCTGGGTGGAGTACAG CCATAACCAGACAGCAAATGCCCCGAGGGCTGTGCCAGGGTGATGTCATGCCTGGGGACG GGGAGGGCCTCTCGGAAGCCCTGGCCTCCTGGTCCTGGCACCCAAGCCCAGGCCTGGGGC TCCCAGCCAGCTGGAGGCAGGGAGGCATTGCATCAGTGCAGGGGAGGAGGAAGGCCCAGC CTGGCCCCAGGCCATGGGTATGGGAGATGGCCGGGCTCGTGAGGGCCTCTCCTCTGGGCT GTGTGACACACACCCTCAGCAGGAGACCCCTGTGGCCTCTGAGCCCACCCCTGCCTGGGC CCAGCGCGTGCCGTGATGGCCAGCCACCTCAACGCCACCTTTACGGGCATCCTAGCGGCG TCCTCAGCTGGGTCAGCCCCTAATTAGCATGAGGAGGAATGTGGGCGTAGGTGCAGGCTG TAAATGTGTGGCAGTACCCCCTCCCCCCACCGCGGGCAGAGCAGGTGCTCCGCCAGAGGC TTGCCGGCTGGGCTCAGGCTCGGGTCTGGGCTGGGTGTGACTGATCCTCAGCAGTAGATG GGGTGCCCTAGGCGGACAGGGCACCCTAGGCGGACAGGGAGCCCTAGGTGTTCTCTCAAC CCACTTGACGGCCCTCCTCCTACAGGGGGCTTCGCCACCTTCTCCTCCTGCTTCCCCGGC CTCTGCGAGGGCAAGCCTGCTGCCCTGCTACCCATGAGCCTCTCCCAGCCCTGCCTGCCT GTGCCCAGCGTGGGCCTGACCCGCATCCTGCCTCACCTCTACCTGGGCTCGCAGAAGGAC GTCCTAAACAAGGTGTGTGTGCAGTGGAGTTCGGGGGGTGGTCAATGGGAAAGGGGCAGG AGCTCCAGAAGCAGCTTGGCAGCGGAGCGGGGGATGAGGGAGGAAAGGAGCTGAAGGCAG TGGATGAGCTGGGTGTGGGAGAAGCATGGGTGGGGGCCCAGGAGGACCCCAGGCTCCCCA CCCATGCCCCTGGAAGGACCACAGCAGGGCTTGCGGGAGGGCCCGGCAGGGCTCGGGGGA GGAGCGGGGAGCTGGCATGCCAAGCTGCGGATGTCACTGGGCCTCTGGCCAGCTCTGAAA GAATCCCATGTTTTAAAAATGGTGACGAGGGAAAAGGGTAAAAGCCACCACCCAGGCAAT CATAAAATTCCTAGGAGCCCACCACCAGCCGTGGGTGGGGCCTGCAGTCGGAGGCCAGCC GTGCCCCACCCCCCGCACGGGCCCAGGGTGCCAGGGTGGACCAGAGAGGCCTCCTGGGCC CTCCCCTGGATACACTGGGATCTGGGACAAATTCCAAGGCTCCCAGGATTCTAAAGGCCC TCCTGACGGCAGGGCAGGAAAAGCCTCCACCTTCACTCCCGCCCCGAGCTTCTCCCACCC CTTTCCAACCCGCCCTCCCGCCCCTCCAGGATCTGATGACGCAAAATGGAATAAGCTACG TCCTCAACGCCAGCAACTCCTGCCCCAAGCCTGACTTCATCTGCGAGAGCCGCTTCATGC GGGTCCCCATCAACGACAACTACTGTGAAAAACTGCTGCCCTGGCTGGACAAGTCCATCG AGTTCATCGGTGAGTCTGCGGTGGGCGGAGGGCAGGGACCTGGCTAGAGGAAGGCTAGAG CTGTGTGTGGCCACAGACACAGGAGGGGTCCCCAGGAAGTAGCCGGAACTGTTGGCAGTT GGGCGGGTGGGGTCCCCTACCTGGGCCAGGGAGAAGCTGTGCAGTCTTAGCCCTCACCTG GCCCCCATGGCCCACCTGCCCAGATAAAGCCAAGCTCTCCAGCTGCCAAGTCATCGTCCA CTGTCTGGCTGGCATCTCCCGCTCTGCCACCATCGCCATCGCCTACATCATGAAGACCAT GGGCATGTCCTCCGACGACGCCTACAGGTACCACCTTCCCCAGTCGCGCACTTGTGGCTC ACAGCGTCGCTTCCCTTCCCCCGGCTGCCCACTTGCACCAGAATGACCCCACCGTCCAGG ACCCGTGGCAAGGGAGGAGGGCCTGAGACCAGCCTGGCGCACATGAGCTCGTGGGTGCCC AGCGGGTGCGTCAGGTGGGCAGCCTGGCCCCGGCGGGCGCCTGGGACTGAGCCTCCTCCC CCGCAGGTTCGTGAAGGACAGGCGCCCGTCCATCTCGCCCAACTTCAACTTCCTGGGCCA GCTGCTGGAGTACGAGCGCAGCCTGAAGCTGCTGGCCGCCCTGCAGGGCGACCCGGGCAC CCCCTCAGGGACGCCGGAGCCTCCGCCCAGTCCTGCCGCCGGGGCCCCGCTGCCACGGCT GCCACCACCTACCTCAGAGAGCGCTGCCACAGGGAATGCGGCTGCCAGGGAGGGCGGCCT GAGCGCGGGCGGGGAGCCCCCCGCGCCCCCCACGCCCCCGGCGACCAGCGCACTGCAGCA GGGCCTGCGCGGCCTGCACCTCTCCTCGGACCGCCTGCAGGACACTAACCGCCTCAAGCG CTCCTTCTCCCTGGACATCAAGTCTGCCTACGCCCCTAGCAGGCGGCCCGACGGCCCCGG GCCCCCCGACCCCGGCGAGGCCCCGAAGCTCTGCAAGCTGGACAGCCCGTCGGGGGCCGC GCTGGGCCTGTCCTCGCCCAGCCCGGACAGCCCGGACGCCGCGCCTGAGGCGCGCCCACG GCCCCGCCGGCGGCCCCGGCCCCCCGCCGGCTCCCCCGCGCGCTCCCCCGCGCACAGCCT CGGCCTGAACTTCGGCGATGCGGCCCGGCAGACTCCGCGGCACGGCCTCTCGGCCCTGTC GGCGCCCGGGCTGCCCGGCCCTGGCCAGCCGGCCGGCCCCGGGGCCTGGGCACCGCCGCT CGACTCCCCAGGCACGCCGTCGCCCGACGGGCCCTGGTGCTTCAGCCCCGAGGGCGCACA GGGGGCGGGCGGGGTGCTGTTTGCGCCCTTCGGCCGGGCGGGCGCCCCGGGACCAGGCGG CGGCAGCGACCTGCGGCGGCGGGAGGCAGCGAGGGCTGAGCCCCGGGACGCGCGGACCGG CTGGCCCGAGGAGCCGGCCCCGGAGACGCAGTTCAAGCGCCGCAGCTGCCAGATGGAGTT CGAGGAGGGCATGGTGGAGGGGCGCGCGCGCGGCGAGGAGCTGGCCGCCCTGGGCAAGCA GGCGAGCTTCTCGGGCAGCGTGGAGGTCATCGAGGTGTCCTGACCCCTCCGCTGCCCTCG GCCCCGCCGCCCGCAGCCAGGCCCGTTATAAATGTATATTATATATAATGCAAAGAAAGG TAAATGGTTTTACTGGGATTTTTATCGAGAAGTAAATATTTCGATTTTTTATTTATTTAA GCTGTTCATTCTGGCAATGATTTGGCAACAGTGCGGGTGGTCCTCGAGCTCTATTTTTAC TGTCTGGTATTTAAACTGAAACATACGTTTCTAAGCAATACGAGGCCACCTTCAGTCGCA AGCTGGGTGCCAGGCCTGGGGCCCCTCCCAGTTCCCCCGCCCCAGGAAACACTGCTGACC TTTGCAAAGGCTGCCGAGCTTTCGTGCACTTTTTACATAACAAAAAGGTGAAAAAAAGGA AAAAAAAACTTCTTTGCCACAAACTGAGCCGCAGAACCCCCCTTCTCCCCCCACCCACCT CCCCTGCTCCCTCCCTTCTCTGCGCCGGCCTAGGGCTCTGCACCAAAGCCATAGGATGGA GGAGCAGGAGCTGGTGTGCCCCGGAGAGGTGCGGCCAGCCCTCCATCAGCTCCAGGCACC AAATCTTGGTGGCAAGGAGGGCACCCCGCTGCCCGTTGCCCCAGAGCTGTTCTCTGGCAG GGGAGGACAGGCATTGGGCTTCATGGTGCCAGGGTGTTCAGAGGGGCTGAGAAATAGAAC AGTGTGTGTAGGGGCTTCGGGCAGGGGGTTCTGGAACGTCAGATGAGGTGCAGCCCAGGG GAGGACAGAGGTGTTAGTGCCCCCAACTCCTGCCAGAGCCCCAGTCCAGCCACAGAGTGG CTCAGAAAGGCCATTCCTAGAGGGCTGCGGCCCTCCCTTCTCCCTTGCCCATGCCCCCAG AGCTGCCTGCCGGGCAGGGTGGCACCATTGCAGGAGAGGAGCTTGGCCTCCGGGGGTCAG GCAGGAGGCGCCTGGCTAGCCAGTGCTGGCTCCACTGGGCAGGAAGCCCTGGACCCCCAG GTATGAGGAGGGGGTGGTCTTAGGGTTCTGTTCCAGGTCTGCCCCGCCCCCCTCCCAGCC ATGCCCCAGGCAGAACTTGGAATTCAGGTGTGCACCTGCAGGCTGAGGGGCTCTGTGAGC AGGTGCTGCTCACACAGGGAGTTCAGGCGCCAGCCAAGCCCCTGTGCTGCTGGGATAGGC CTGCTTCACTTAGGGAGCACTGCCTCAAGACAGGTAAAGCCCCCTCGTTTGCCCCCACCC CCATGGGGCCGCTCAGGAGAGAAACTCCCATTCACCCCTTTCCCAGGGTGCTCTCTCTCT AGGTGGCATGCCAGCCCCCAAACACAAGTGGCTTTTGGGCCCAGGTGGGTCAGCCTGCTG CCCCTGCCCCATACCCCCTCGGGCCATTGGGACCCCTGCCCTTCAGATGTCCTAGGGTCT AGGAGTGGGGCCAGTCACTGTGGGAAGAGGCCAGGGGCTTGGCCGGAGAGGCAGCCCAGG GCAGGACCCAGTCCTGAGTCCTGGAGCAGGGCCAGGGAGGCGCCCATCCCGCCCCAGCCA GCCGCCCTCTCTGCTGTTTCTTCTATTTGTTCTTCTTTTCACCCACAGCTCTGTGTTCCT GTCATCCCTCCTTTCAGCAAAAGTCCTGTTCCCGTTCCCTCTGTCCCCACCCACTCCTGT TCCCCCAAGAAAATAAGCTATCGTTGTATTTGCAATCTATGGATTAGAGGTTTAAGTATT TATTATTATTGGTTAATTATTATTAATTATGTAAATTTGCCTCCCATATGTCTGTTGCGT TGGGTTTCTGAGGAGACCCTGGGTGAGGAGGATGCACTGGCTTCCCGCTTCTCGCCCCCC ACCCCTGTGCTGTCCGGGAGACAGTGGTCTGGGGCCACTGGTTGGGCCCCCTTCTCCCTT CCCCCTTCCCCTTGTCCCTTCTGCAGGCCGTTGAGGGGGGCTGTCTGTCTCAGTCTGTCT CTGCTCCCACTCTTGAGGCACTGGTTACCGCAAAGTGAGCAGCCAGCAGGGGGGCGAAGG TCCTGTGTTGGCCACTGCCTCCTCCAGTGCTGCAGGAGGCGGGCTGAGGCCCCACCTGGT GGCTTTCACCTGACCCAGCCCTGAGTCCTCTCCAAGCCTCTCTCCGGCCCCTCCCACCTG GCCACTGCCTCCTCCAGTGCTGCGGGAGGCGGGCCAGGGCCCCACCTGGTGGCTTTCACC TGACCCAGCCCTGAGTCCTCTCCAAGCCTCTCTCCGGCCCCTCCCACCTGGCCACTGCCT GGCATTGGGATCGCCCCAAAATGGACCCGGCCCCTCCTGTTATTTGCTGGGAAGTCCAGC GGAGGAGAGGGTGCAGGTCCCCCGCTGAGCCTCCAGTCTCTGTAGACTGGGCTGCCGGCC CTTCAGCCCCCCTTGGAGCCCCTCCCGCCACAGCCGCACCTTCTGCTCCCGGCCCCTCCC TTTGTATTTGGAGACAATGTGTTGTAATAAAGCTTAAAGTGGATGTTTTC OMIM ID 602038