| Entrez gene ID | | 18780 |
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| Official gene symbol | | Pla2g2a |
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| Full name | | phospholipase A2, group IIA (platelets, synovial fluid) |
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| Aliases | | EF,Mom1,Pla2,sPLA2,sPla2-IIA |
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| Gene summary | | Proteins belonging to the phospholipase A2 (PLA2) family hydrolyze phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2s. The secreted enzyme binds to heparin on the cell surface. Mutations in this gene increase the occurrence of intestinal polyps caused by a dominant mutation in the adenomatosis polyposis coli gene. A frameshift inactivates this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in other strains. [provided by RefSeq] |
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| Location | | Chromosome: 4 Locus: 4 D3|4 68.0 cM |
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| Gene position | | 138387772 - 138391104 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 3333 bp |
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| Gene sequence |
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