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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EFNB3 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 1949 Official gene symbol EFNB3 Full name ephrin-B3 Aliases ,EFL6,EPLG8,LERK8, Gene summary EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq] Location Chromosome: 17   Locus: 17p13.1-p11.2 Gene position 7608520 - 7614693  Map Viewer Gene orientation plus Gene size 6174 bp Gene sequence >EFNB3:7211894..7218067:Length=6174 GGTTTCCTCCCTTAGCCCGCTGCCCTCAATCCCAGCGAGGCTGGGGCTCCGGCTCGGCGC CCCCTTCCTCGCTCCCTGGTCCGGCGCCCCATGCCGCCCCCGCCCGGTCCCCGGCTCCCC CAGTCCCCCACTTAGGCGGGCTCACAGATCCCGGGGTGCTGGCGCGTGGGCCGGGGGCGC GTAGGGCGCCTGCAGACGGCCCCTGGAAGGGCTCTGGTGGGGCTGAGCGCTCTGCCGCGG GGGCGCGGGCACAGCAGGAAGCAGGTCCGCGTGGGCGCTGGGGGCATCAGCTACCGGGGT GGTCCGGGCTGAAGAGCCAGGCAGCCAAGGCAGCCACCCCGGGGGGTGGGCGACTTTGGG GGAGTTGGTGCCCCGCCCCCCAGGCCTTGGCGGGGTCATGGGGCCCCCCCATTCTGGGCC GGGGGGCGTGCGAGTCGGGGCCCTGCTGCTGCTGGGGGTTTTGGGGCTGGTGTCTGGGCT CAGCCTGGAGCCTGTCTACTGGAACTCGGCGAATAAGAGGTGAGTGGCCTGCGGCTGGGG AGATCCCAGACCCTAGGGCAGTGGGTAGGGAAGCTCTGGGGGCTTGGAGGCGGGCTTCTG TGGGCAGGGAGGAGGCGGGAGGGAAGGTGCTGGTGCTCTGATGTGTGATGGGTTACTAGA CAGGTGATCTTGGGAGCCAGACTCCGGGTCCCACGCAGAGCTGGATGCGGGTGGTGCTAT GGATGTCAGGAGTTTGGAGACCCCAAAGGGGCAAGGAGAAGAAAGTTCATGGGTAGCCGG GAGGGCAGTGAGGTGGGTATTTGGATCTGTGGGAGGCCTGCGTCGGGGGCTGGGCTTGGA GGGAGCCTGGTTACTGTCAGCTCTCAGGAGAGAGCTGCAGATTAGGTGCTGCGAGTCGCT GAGGGGAAGGCAGGGCAGGGTGCCTCCCTCCCCCAGAGGGACTGCGCATCCGAGATGGGA GGCAAGGGGGTTCCGTTTGGGGGCTCTGGGGACAACTTCCCCAAGGCTCCTTGACTCTCT TCACAGTCTGTCTCCCAACTCTTCCCCACAGCCAGAGGGTCAGTGAACTGTTGGCTGAAC GATTTCCCAGCCAGAACATATTCCTGCCTTCCTGGCTTGCCGGCATCTTGCTGGAAGAAG CCTGGAGCCCCCTGAACCCTCCTTCCTTCCCTTTTGCATCTGGAGGACTCCATTGCCCCC TCCCCCAATCTTTGCTGCAAACTCTTCCATCAGACCCTCTGTTCCATGGCATGCCAGCTT TGCTCTGAAAAGAGGCCAGGGGTCAGATGAAACTTCAAGCCACGCTGGGTAGGACAGAAC CTTCGGGAGGTCACCTGGGTCCCTTGCCTACATGCGGATCCCACTTCCCGCTCATAAAAG AGTTCTGTGTTTTGAAAAATTCCTACTTCCCTGGGGAGACTGTGTGAGGCCATGGGAAGG GGGTGGGCTTTGGAGCTCATCAAATCTTTGGTCTTAATCCTAGCTCTGCCGCTTTCAGCT GTGTGGCCTTGGGCATGTCACTTAACCTTTCTGAGTTTGTATCCTCAATCCTTACAGCTA TTATGAGGATTAGCGGTAAGGTGTTTGAATGTATTATGTGCTCATTAAAGGAGAGCTAGG ATTATTGTTCCTCTCTTTACTTCCCAGCCTCCCTCACACTTCTCTGCTCTGCCATCCCTC CCTCTCTTTTCCCTGGATCTCTTTGGGTATAATCTCAATGTCTTTTCTGTACTCAGTCAC CCACCTGCCAACTCCCAGCTGCAATGTGAGTATCAGGTGTGTAGCTTGAGAACATAAGCT TGTTTTCACAGGGTAGAGAAAAGGGAGTTAGGGTGTCCTGGGGGCTCTTTCGGATGTGGG GTGGGAGTGGGACACTTGGGAGTCTGGGAAGATATCAAGTAGCAGTCCCCTGGGACCCAG TCCTGAGACCCTGTCTCAGCAGCTATTGATGTCCAGGAAGGGGCTGCAGGGGTTGGCAAG TTGTGGCTGTGCTGGGACAGTGGATGCCTGGGTGCACTGGCCAAGGAGATGGTGAAGTGT GTTGGTTGTGGTTAGAAAAGTCAACTCCTTTCCTTTCCAAAGCAATAGAGCACTTGCCCC AGAAGTCTAAGACCCAGTGTGGGATTCTGAGTGGGAGAATGACTCAGGCAGCAGGTTCCT AGACCCTGGTTCCCATCAGCCCCAATGATGGTCGTGGCCAAACCAGGCATTTGCCTTCTG TGCTATTAGCTGGCTAACTTAGGACACTGGTCTGGACCACCCTCCACACAGCCCCTCCCT GAACCGCCGCCCCCTTTGCCCGGAAATCCCTGAAATTCAGTGGTGGCCTGAAGGAGGGGA GGCTCTGCCCGCATGGTTGGCTGCCATGGAATAGTGAAATCACCTGGGAGGGGTGGGCTG TGTGGTTCCAGAGAGGCCAGCTCCTTGGTAACTGGCATCCTGTTGCCATGGCAACGGGGC TGGTGATGGAGCGGGAGATGGCGGTGTGCATGTGGTGAGGGCGGGCTGAAGAGTGGAGTG CATTTGGGCACACCAAGGGGCAGGAGACCCCTGAGCCTGGCTTCCTGCTGCTTCCAATGT GAATGCACAGAGTCCTTGGTGCCTGCTCTATAAGAAGAGACTTTCCACTCAGACAAAGGC GGGCAAGCGTGAGCTGAGAATTGCTGTCCTGGAAGGTTGTGGGGTGAGGGAAGGAAAGTT CTGGGGGCCAGGCCTCTGACATCTCTTCCTTGTCCACCTTACCCTCCTCCCCATAGGTTC CAGGCAGAGGGTGGTTATGTGCTGTACCCTCAGATCGGGGACCGGCTAGACCTGCTCTGC CCCCGGGCCCGGCCTCCTGGCCCTCACTCCTCTCCTAATTATGAGTTCTACAAGCTGTAC CTGGTAGGGGGTGCTCAGGGCCGGCGCTGTGAGGCACCCCCTGCCCCAAACCTCCTTCTC ACTTGTGATCGCCCAGACCTGGATCTCCGCTTCACCATCAAGTTCCAGGAGTATAGCCCT AATCTCTGGGGCCACGAGTTCCGCTCGCACCACGATTACTACATCATTGGTACTGCTGGG CAGAGGGCACGATTGAGTGGGGGGCTCCTGATACTGAGCAGAGAGGGAGGGGGACCCCTG CAGCCAAGAGGGAGATCCCAGTGCCCTCAGGCAGTGTTCACACCAGGGTGTGGGGCCAGA ATCAGGGCTAGATTCTGGAGTGCCAACCTCTTCCTCTGGCTTTTCTCTCCCAGCCACATC GGATGGGACCCGGGAGGGCCTGGAGAGCCTGCAGGGAGGTGTGTGCCTAACCAGAGGCAT GAAGGTGCTTCTCCGAGTGGGACAAAGTGAGTGGGGCTGGGGGACACCTCCTGGGCACGA AGGGACGTTGGGGCAGTACGATCATGGTTGGGGCAGTTGTCTCAGCCCCTCTCTGGGTCT TCCTCATCTCCAGGTCCCCGAGGAGGGGCTGTCCCCCGAAAACCTGTGTCTGAAATGCCC ATGGAAAGAGACCGAGGGGCAGCCCACAGCCTGGAGCCTGGGAAGGAGAACCTGCCAGGT AGGAACCAGGGGCTAGGCCCCTGCCTTCCCCAGCTTCCTCTGCTCTCAGACCCCAGCTGC CCTGCCGTCACCCTCCCTCCCTCTTCAGTTTTGGGGGCGGTGATACAGGAAAGAGGAGAA GAGAGGATGGGAGGGTGGGAGGGGAATGGAAACCAAATGAGGAAAAGACTCAATTAGAAC TAATTAGCCAAGTCAGTGCTTCAATCAGTGCTGTCAGAGAAGTGGGGAGGACTCCGTGGC AGGAAGCTGAAGGGCTGGACACCTGGATTCTGAGCAGAGTTCGGAGGGGGAGGAGAGATG GGGTCCCCAAGGGGCCTGGGCGCTACAAGGGAAGCCCATGGGGACCCCCAGGGTTGGGTG TCCAGGTGCCCAGGTGGCTCCTTCAGTCCCTCCCCCTCTTTCCTCCTTCACCCCTTCCCT GCCAGGTGACCCCACCAGCAATGCAACCTCCCGGGGTGCTGAAGGCCCCCTGCCCCCTCC CAGCATGCCTGCAGTGGCTGGGGCAGCAGGGGGGCTGGCGCTGCTCTTGCTGGGCGTGGC AGGGGCTGGGGGTGCCATGTGTTGGCGGAGACGGCGGGCCAAGCCTTCGGAGAGTCGCCA CCCTGGTCCTGGCTCCTTCGGGAGGGGAGGGTCTCTGGGCCTGGGGGGTGGAGGTGGGAT GGGACCTCGGGAGGCTGAGCCTGGGGAGCTAGGGATAGCTCTGCGGGGTGGCGGGGCTGC AGATCCCCCCTTCTGCCCCCACTATGAGAAGGTGAGTGGTGACTATGGGCATCCTGTGTA TATCGTGCAGGATGGGCCCCCCCAGAGCCCTCCAAACATCTACTACAAGGTATGAGGGCT CCTCTCACGTGGCTATCCTGAATCCAGCCCTTCTTGGGGTGCTCCTCCAGTTTAATTCCT GGTTTGAGGGACACCTCTAACATCTCGGCCCCCTGTGCCCCCCCAGCCCCTTCACTCCTC CCGGCTGCTGTCCTCGTCTCCACTTTTAGGATTCCTTAGGATTCCCACTGCCCCACTTCC TGCCCTCCCGTTTGGCCATGGGTGCCCCCCTCTGTCTCAGTGTCCCTGGATCCTTTTTCC TTGGGGAGGGGCACAGGCTCAGCCTCCTCTCTGACCATGACCCAGGCATCCTTGTCCCCC TCACCCACCCAGAGCTAGGGGCGGGAACAGCCCACCTTTTGGTTGGCACCGCCTTCTTTC TGCCTCTCACTGGTTTTCTCTTCTCTATCTCTTATTCTTTCCCTCTCTTCCGTCTCTAGG TCTGTTCTTCTTCCCTAGCATCCTCCTCCCCACATCTCCTTTCACCCTCTTGGCTTCTTA TCCTGTGCCTCTCCCATCTCCTGGGTGGGGGCATCAAAGCATTTCTCCCCTTAGCTTTCA GCCCCCCTTCTGACCTCTCATACCAACCACTCCCCTCAGTCTGCCAAAAATGGGGGCCTT ATGGGGAAGGCTCTGACACTCCACCCCAGCTCAGGCCATGGGCAGCAGGGCTCCATTCTC TGGCCTGGCCCAGGCCTCTACATACTTACTCCAGCCATTTGGGGTGGTTGGGTCATGACA GCTACCATGAGAAGAAGTGTCCCGTTTTGTCCAGTGGCCAATAGCAAGATATGAACCGGT CGGGACATGTATGGACTTGGTCTGATGCTGAATGGGCCACTTGGGACCGGAAGTGACTTG CTCCAGACAAGAGGTGACCAGGCCCGGACAGAAATGGCCTGGGAAGTAGCAGAAGCAGTG CAGCAGGAACTGGAAGTGCCTTCATCCAGGACAGGAAGTAGCACTTCTGAAACAGGAAGT GGTCTGGCTGGAACTCCAAGTGGCTTAGTCTGGGGGATCAGGAGGTGGGAGGTGGATGGT TCTTATTCTGTGGAGAAGAAGGGCGGGAAGAACTTCCTTTCAGGAGGAAGCTGGAACTTA CTGACTGTAAGAGGTTAGAGGTGGACCGAGAAGGACTTTTCCCAGTCTTCAGTGGCACTT CCCAAGATCTCCCTTCCCTTGTGCTCTGTGCTGATTTTAGGACAGCTAAGATGACTGCCA TGTGCTGTGGCAGGCCTAATTTGTCTTGTTCTTTCCTTTCCATATCCCAGTATAATCTCT GTTAATCAACAGGACTACCCCAAGAACCCATGTGCTCTCCCGAGTAACCCAGATGGCTGT CTTGTTCATTCCATCCTACATTTCTGACTCCTTTCAGACTCAACACAGTTCCCTTCTTAG TGACCAAAATGGTGGCCTACTGGCTGGTCTAGCTGACAGTGGTACTTAGCAAAGGCCACT GTTTCCATAGTGACCAGCTGATACCTCTTCCTGCCCTCTAGTGTGCAATTGGGTGTTGCC TCAGTTTCCTCCCAGCTCAGTTTTATTAGATCAAAGCTGTTGTTGGGCACCAGGTTGGCC ACCTCAATCACCAGCCAAGATGGTTGCTTTGTCCACCAGAGGTCAAGTTCACCTCTCTGG TGCTGTAGTTCCCAGCTCCTTCCTGATTTTTCTAATCGCTCCTTCTGGGGAACAGGAAGT TGATATTGCCATGGTGGCGGGGTATGCCGTCACCTCAGTAGTTTTACTGTAAAAGGGAAA TTTGAACAACAAAAACCAAAAAAAATAAAAATAAAAAACTTCAAAAGTTGACAA OMIM ID 602297