Entrez gene ID | | 1982 |
Official gene symbol | | EIF4G2 |
Full name | | eukaryotic translation initiation factor 4 gamma, 2 |
Aliases | | ,AAG1,DAP5,FLJ41344,NAT1,P97, |
Gene summary | | Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11p15 |
Gene position | | 10830582 - 10818593 Map Viewer |
Gene orientation | | minus |
Gene size | | 11990 bp |
Gene sequence |
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OMIM ID | | 602325 |
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