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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EIF4G2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID1982
Official gene symbolEIF4G2
Full nameeukaryotic translation initiation factor 4 gamma, 2
Aliases,AAG1,DAP5,FLJ41344,NAT1,P97,
Gene summaryTranslation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq]
LocationChromosome: 11   Locus: 11p15
Gene position10830582 - 10818593  Map Viewer
Gene orientationminus
Gene size11990 bp
Gene sequence
OMIM ID602325