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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ENSA (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 2029 Official gene symbol ENSA Full name endosulfine alpha Aliases ,ARPP-19e,MGC4319,MGC78563,MGC8394, Gene summary The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] Location Chromosome: 1   Locus: 1q21.3 Gene position 150602098 - 150594599  Map Viewer Gene orientation minus Gene size 7500 bp Gene sequence >ENSA:complement(2083241..2090740):Length=7500 TCGCAACGTCACGGGCAAGGGCCGCCATTTTGACTGAGCAACCCTAGTGACAGGAGCCGA AGCAGCAGCGCAGGTTGTCCCCGTTTCCCCTCCCCCTTCCCTTCTCCGGTTGCCTTCCCG GGCCCCTTACACTCCACAGTCCCGGTCCCGCCATGTCCCAGAAACAAGAAGAAGAGAACC CTGCGGAGGAGACCGGCGAGGAGAAGCAGGTGAAGTGGAAGGGGTGCGGGCGGGCGAGCT GGGGAGACCGTGATGGGGCGGGAGACGGTCTCCCACCAGTGCGGATTGGTCGCCATGGTC TCAGGCTCCGCAGGGGTTGGCCACTTTTTGCGTCACGCTGGGTGAGCTTCAACACGACAT GCTGCTTTGGCGCTGGTTAGTTGGGTCGTTTGTCACTCAGTACTGTACTCTTCCTGATTG GCCAATAGGCCTACCGCTCAAACCTTGGACGCTGTGCTATAATTGGCCGAGCATGGACGT GGGGCGGGTGGTTGGAAAGACGGTGAATGGAAAGGGGATGGCTGGTGGTCTTGGGTGTGA TGTGTGTTATTGGTTTGTAGAGGTAAGTGACCCAGCAACCGGGCTGGGGCCCGCAGCCTC AATCCGCAAAGATAGGGGTCGAGGTAAAGACGTTTAAAAAAAAACCAGTATTGGGGGAGG GGAGAAGTGTAGTTATTATAATGGCTAGTTTAAGGCGGCAACTTTCTCAAGAGACCTATT TTAGTAGCTAAGGATGGTCTATTGCTCACCTTCAGTGAGGACCCAGCAATATTGAAGAGG GCTAGAGTTCCAAACAGAATCATGGTAATTAAACTTGGAAAAGACGCCGACAGGGTCGTG AGAAAGACACTTCTCTCTTCCCCTAGACTTCCAAGGCAGGGACTTAGTGCACCTGCGATT CCGTGATGGAAACACTAACGCCAAATAAACCCCTTATTGGGGTTTGTATTTGACTTTTAA AATTTAGTACTGGGTTCAGGTACTCATTAAATACACTTGGTGTTATATCTATGCGTAATT TCCAAGAGAAAGGAATATAATTCCACTAAAAAGAGTCATACGTTGACTTCATATCTTTTC AAAAAGTCACTAAAGGGCAGCAGGGACCACAAAAAAAAAAAAAAGAGATTGACTACAGTA GTGAGAGTCCCTGCACCACCAGGGTAGGTATTGATTTTTTTGATGAAAACTGGTGGGTAA ATACTAGTGAGCCTACTGTATCTTTGTTTTCCTGAGGTTAAAAACAGTATCATTTTCCTC TCTGTTTATCAGCTTGCTACCATAATATTTGTGGAAATGTTGAAGCAAGGCTGTGCCATT ACTCAGGTGGAGATCTTTGGAGAAGGCCACATAGCTAGCCGCCTCCACAGGGAGACCTAA CAGGTGGCTTAGACCTTGAATAAAGAAGGAACTGCTTTGTCGTGTAGCAATTTTAAAAAA GAAAGAAAAAAATAAGGAGGAAACATTTAGCAAACTATTTTTTGTTGTTGTAGAGACGGG GTTTCAACATATTGCCCAGGCGGGTAGTGAATTCATGAGCTCAAGTGATGCACCTGCCTC AGCCTCCCAAAGTGCTGGGATTACAGGCATGAGTCACTGCTCCCAGCCCCAAACTATTTT TTTTTTAATTTCTCATGTGACATGTAGGATAGCCTAGGGAACCCTGCTACTCATCCTCTA TCACCAGAAGCCCTGCTTTTTTCTCTTTGTCTTTCTTAGCATTTGTGCTGAGTGATATGG CCCACTCTGTGATTAAAGTATTGTGTTTAGTATTACCTTTAGCCCAATACGCACAGGTCC CTGGCTGGTTCCTTGGGTGAAGTGTGAGAAGCAGCTTGTCTTTTTCTCTCACAATAGTCA TCTTGAGCTTTAGGGATTTTAACAAAGGTCTAGCTTTAACAGCAGAGTAGAGATAGCGTA TTTACAAGTGGGTGGATTTCCAGGAGAAGTTGATAGTATAGTTGTTATCAGATGTGAGAA GCTGTTGTTTCTCAGTCTTTAATTTTATTTGGCTCATTTGTTTTCTCCAGGACACGCAGG AGAAAGAAGGTATTCTGCCTGAGAGAGCTGAAGAGGCAAAGCTAAAGGCCAAATACCCAA GCCTAGGACAAAAGCCTGGAGGCTCCGACTTCCTCATGAAGAGACTCCAGAAAGGGGTAT GGGGCATAGTCTCTTACCCTCTTTCTTTGGAGCTAAAGGAGGTTCTTCGAATGAAGTCTG TAGAGGTTCTACTGGATCCTTTTCTGGAGGTTTTGTTGTTGAACAGAAGTAGAGGCGAAT TTGAAATTTGAAAAGAGCAAGTCAAATTAATGTAAATCCCTGATGTGGTATCAATTCCCT CCTGATTTCCCATGTAGGAAATTAAGGCCTAAATTGGAGCATTTGGGTGTGTGGGGAAAT GAGGGAAAGATGTTAGAAACTGAAATGCAGACTGCCCCCAGGCATTTGCCTGTTTGAATG TTGGAGGTTTTAGGATTGTGCACTTTTTAAGCATTAGAGATAAATTTTGGGATGCATCAT TTCAGAAGAAGATCAAACCATCTCTCCTACAGAAATAAATCCTCAACTTGAAATGAATCA GTTTCTTCATACCCTTGAAGTGAGCACCAGCCATTAATTATACTCCTGCAGCAAATGTAT TTTTCTTGTTCAGAGTGGTCCTCCTTACCAAGAGAGAGTCTACTTTCATAGCCATGTAGC TCCTGATCAGATTTTTAGTTCCCAAAGGTACCTAAAGCTGACTGAGGGATTATATTATCG TTTTTTAAAAAAAAAATTTGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTTG GGAGGCCGAGGCGGGCGGAGCACGAGGTCAGGAGATCGAGACCATAGTGAAACCCCGTCT CTATTAATAATACAAACACTTAGCCGGGTGTGGTGGCGGGCGCCTGTAGTCCCAGCTACT CGGGAGGCTGAAGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAG ATCGTGCCACTGCACTCCAGCCTGGGCAACATAGCGAGGCTCCATCTCAAAAAAAAATTT TTTTATTTTCCTTACTCTCCTCTGCAATGACTGTAGGATTATAAATCATTACATTGGAGT GTGCTTCTCTGTGCGGATGAAATGGTGGGTGAAACATCCCTGTGGAGGATCCCAGTTATT GAGTCTTAGTCACAGATGATAATGTGATGCTGATTTGCATTTACCTTGCTGGAGGCAAGG CAGGCGTGGGCAGGCTGTCACAGTCATGGAACATGTGTGGGAGCTGTGAGAGTCAGAAGG AAAATACATTATCCTCATGAACAGGCCCAGTTTCTATTCCTGGTCTGGGAGAATAATCAT TTTGAGGTTGTTGGCTTGTGGTTGATCTCCTGGTGGCTAGGATAGCCCCATATTTATCCT TCTCTATATCTTATTCATTTCTGTTTCTCCAGTTCCAGGCTATTGCCCTGTACCCAGTAA GGTCCTCAGTTACCCTTTATGAATAAGTGATTTTGGTGGAACGATCCTCTACTGAGTGGA GTACAAAGGATGGCAGGGGCTATCCCTTGACTCCAAAACTATATACTCTAGCTGGGAAAT TGCTTATGTACCTGAAAAAGTCAGAACACACTGGGGAGAAGACATAAGTACATGTAATTA ATGTTAAACTGTGTATGCATGAGGTTAATCAAGGAAGACTTCTTGAAAGATCCGAGTGTG CATGAGGGTTTATAATGGATGTGAGATGTGAGTCTCCTTGTTTTTGAGGAAGGCCAGAGT CCTCACTCACCTAAACCTCCCTCTTATCTCTTAGCAAAAGTACTTTGACTCAGGAGACTA CAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGAA CCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCT CGTCACCAGCAAGCTTGCGGGGTAACCTGAGCCCCCCTCTCCTCCCCTTCCTCAACCACT GGACGTTTATATATTATAGGCAGGGATGAAATGGGCACCTAGTCAGATCTTCTCAGCTTG CTAGCCAGAAATGACTGTGATTCTGCTGGGGGCTGCTGAGAAGGTAATGTAGGTTGAAAA GGGGCTCTAAGTTTATTTATTTCGTTAGATTGACACTTCCACACACTCCCTGTAGTCCAG GTAGGGCCCAGAAATAGGAAAGGCTAGGATTGGATAATGCTGCAAATGCTTTTTTTGTGT GAGAAACTGGAGAGATGTGATTTCTCCTTTTGGGAGAGAATGTCCCAAAATTGATTAGGC TGAGCCTTGGGAATAGTTTGGCAGGTTTAACATCCCAAGGCTAACCTAACGTAGTTGGGA AAGGTAGATTGAATGAGACATGTTTTCTGTGCTTCTAAGTGTTCTGTCCCTTAGGCTGCT ATTGCTTCATGTTTCCATTATGGCAGGTTTAGAGAATCCTTAAAAAGAAAAATTGACTTG CTTGCCTAAAACTACAGTGCCCCCTTAGCCTCCATTACTTAGTATCTCTTACAGTTTGCT CTGGCTCTCAAATAATATAAAGATTGATGAACATTATTCACAGAAAATGGGCACCTTCTC TCTCTCTTCCAGCATGTTGCTTTTGAAAGTATCATGGGATAGTGGGACGAGCACTGGTTT AGGAGTCAAGATATCTGGGTTCTCACTCTACTCAGTCCCAGCAGAGCTGTTGTATAACCT TGATTAAGTCATTTAGCCTCTCTGGATTTCTATTTCCTCATCTGTAAAATAGAGTTAAAT GTATGTAAGATTGATTCTGATTCTGAAGTCTTAACTGCCAGCAGAAAAACTCCATACTGT TCATTGTAAAACTAAAAGTGAGGAAGGCTCGTGGGTGGTGAACCTCTGCTCTGTAATACT GGGAAAGTACTACAGAGGGGAACCATTTGAGGGATACATGAGGAGAGAGTAAATTGAGGT TTGGGGATTATAAATTCAGGCAAGAGAACCTTATAGATATCACAGTCTTGAGGGTCAAAA AAAAATACTTAGGAAGCTAGCCATGGAAGCTTCTTGCCTCTGACCCAGCCCACTTTCCCA GCCTACCTCTGGGCCTTAGCTGCTAAAAAGCTTCTCTGGCAGCGGAGCTGCAGGCCTGAG GAAACATGCTCAGTCATGCACATGTGTTGACCCATGTTTCAGATGCAGTCTGATGCCAGG TATATTGTTAGGGAAAGAGGAAGAAGGGTAAACTGAGCTAGCCCCTGGGGCTGAGTACTC CTGCAGGGCTGGAGGAACAGGTTCTTAGAAGATGATTCACCTTGGAGGAAGCTGGGGAAA GTGGTTAGGGAGGGAGAGGAGGAAGACTGAGAAATCTCTGCATCCCCAGAACTCAGCAAC CCAGCTCTTTTATCATGAGGAGAGGTAGCCATGCTGACTCATGAACAGGTGGAGGAAAGG GGTTGCAGGTGACCAGCATCTTCAATCTAGTTACCACCAGCTTGGCTAGAATTTTATTGA ACGCAACTTGCTAGTTATGACAGAGAGGACCAGGGTGAGAACTAATGCTCAAGAGAGCAA GATTCTGTAATCCTCTTGCCCTCTCACATCACAAATTCTGATATGCCAAACATTTGGCCC AATGAGAATGACTGATAGACTTGCTGATGTGCATGTGGGGGGATGAGGTGTGTATATGCC TTTCTCCTGACTGGCCATTCAGTGTTCAGGCTGTCATTCAAATTGGATAGGAGAAAGTTG GTGAGGAAGGAATGGAGAGAGCAGGATCCCTGGACTCCCTGGTCCCCAAACTCCTTGACT GTCACTTGTAATTGTATATAATTTTTGTGTTTCTTGCTCCATTTCCTCATGCTGTCATCC TTAAAGTCCATCTGGGAAGGGGAAAATGCTGAACACCATTGTATAGTTTCTTCAACTGTC CCAGCCATGTTGTACATAGATATGTCATGTTATTATATATATAAATATATATATAATTTT GTACGTTTTCTTCATCTCCGATCTTCTCAAATTCTGTACTTTTTTTCTTTTCTGTCTGAG CTGCCTTCTCTATCATTCAGCTTGAGTCCTCAAGACTACTGGTCACAATGAGTCTGATTT TTAGGAAGGAATAGGAGGAGCAGGGAAATCAGAAAAACTGTTGGTCTCACTCTGTCTCTC TACCTGGTCATCTTCAAGGCTAAGAAAACAAACAAGCTACATTCTGTATTTGCCAGTTTC CACAGCATGAAGTACATAGCTTCCTTAGCAAGGAGTGGTCATTCCAAAATCCAAATGCAA ATTGCTTTGATTAAACCTAGATTATTAAATCCATTCAGAACAGCATGTGTGTGGTCTGGT TCTGGCCTCCACACAGTCACCACCTCATCTCTGTGCTACCTCAGTCTTTGCAAGTAGCTG TGGCCATGCCTCTGAAACAGCCTGCTCTGAGCCAGGCAGCTTACCCACCTGGAAACCTCC AGTTATTTTGATCTTATCTAAAGAATTATTTTTCTATGTTTGTTATCCATGGATATCCCA GAAAGGCAGATAACGTTGTTTCGTGGATAGGAAAAGACTGAAATTCTATTTTTTGATTTT TTTTGCAACTCCCTTATGGATAGGATTGAGACATGCCAGGTAGCCTAATGGTTGTTAAAT GTGGAGGAATCATGGGGTAGAGACTGGGTTGGAGTTCAGGGTTTTTTTCCCCTATTACTT GACAGTGTTGTTTTTTTTTTTTTTCTTCTGTGTTCGTCCGCAGTGGCCAAGTTGAATGAT GCTGCCCGGGGCTCTGCCAGATCCTGAGACGCTTCCCCTCCCTGCCCCACCCGGGTCCTG TGCTGGCTCCTGCCCCTTCCTGCTTTTGCAGCCAGGGGTCAGGAGGTGGCTCGGGTGTGG GCTGGAGAGGCAGAAGCCCTTTCCTGTTGGTGTCCCAGCACATGGAGCCCCTTGGGCTGA GCACCAAGACCTTGAACCTTTTTTGTTTTACCTTTTTTCCAAATAACAGTTGGGAGAAAT ATCAATGAAATTCTGGGGGTGGGGGTGGGGTTGAAAGGGTGGGGTGGGAGATATGGAGGA GTATGAATTAGGGCTTGGAGTTGGTAAAAACATTCCTGACTATCCTTCTTAACCACGTGG CTGATGTGGGGTAGGTATGAGGGGAAGGAAGTGGAGTAGCCTAATGAAAAGGGGTTCTAG TTGAGCTCTGTAGATAAATGCCTTGTTTCAGTGTGGTTGGAGACCTGGTGTCAGATAAAA GAAACTCCATCCGCACAGACAGATGCAAACAGCTCCTCTAGTTCTGCAGAGCTAGTTGAG AACTCAACATTAATCATTTTAAAAAGTACTGTCCTTGAAATAGATTTGCTGTGGGAAGAA GGGCAGTGAGTGTGGGAGAAAGGAGCCGTGAGCGTGGGGAACCCCACAGAGCCCAAAGGA CTTTTTCAGTATTCGAAATAAACAAAACAAAAACCCATGAAAAAACCCAACCCAGAAATA OMIM ID 603061