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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NLRP11 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID204801
Official gene symbolNLRP11
Full nameNLR family, pyrin domain containing 11
Aliases,CLR19.6,FLJ26273,NALP11,NOD17,PAN10,PYPAF6,PYPAF7,
Gene summaryNALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM]
LocationChromosome: 19   Locus: 19q13.42-q13.43
Gene position56348128 - 56296763  Map Viewer
Gene orientationminus
Gene size51366 bp
Gene sequence
OMIM ID609664