Entrez gene ID | | 2050 |
Official gene symbol | | EPHB4 |
Full name | | EPH receptor B4 |
Aliases | | ,HTK,MYK1,TYRO11, |
Gene summary | | Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q22 |
Gene position | | 100425143 - 100400187 Map Viewer |
Gene orientation | | minus |
Gene size | | 24957 bp |
Gene sequence |
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OMIM ID | | 600011 |
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