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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for EPHB4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2050
Official gene symbolEPHB4
Full nameEPH receptor B4
Aliases,HTK,MYK1,TYRO11,
Gene summaryEphrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q22
Gene position100425143 - 100400187  Map Viewer
Gene orientationminus
Gene size24957 bp
Gene sequence
OMIM ID600011