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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for AKT1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID207
Official gene symbolAKT1
Full namev-akt murine thymoma viral oncogene homolog 1
Aliases,AKT,MGC99656,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA,
Gene summaryThe serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
LocationChromosome: 14   Locus: 14q32.32|14q32.32
Gene position105262080 - 105235686  Map Viewer
Gene orientationminus
Gene size26395 bp
Gene sequence
OMIM ID164730