Entrez gene ID | | 210 |
Official gene symbol | | ALAD |
Full name | | aminolevulinate dehydratase |
Aliases | | ,ALADH,MGC5057,PBGS, |
Gene summary | | The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q33.1 |
Gene position | | 116163618 - 116148592 Map Viewer |
Gene orientation | | minus |
Gene size | | 15027 bp |
Gene sequence |
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OMIM ID | | 125270 |
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