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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ETF1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2107
Official gene symbolETF1
Full nameeukaryotic translation termination factor 1
Aliases,D5S1995,ERF,ERF1,MGC111066,RF1,SUP45L1,TB3-1,
Gene summaryTermination of protein biosynthesis and release of the nascent polypeptide chain are signaled by the presence of an in-frame stop codon at the aminoacyl site of the ribosome. The process of translation termination is universal and is mediated by protein release factors (RFs) and GTP. A class 1 RF recognizes the stop codon and promotes the hydrolysis of the ester bond linking the polypeptide chain with the peptidyl site tRNA, a reaction catalyzed at the peptidyl transferase center of the ribosome. Class 2 RFs, which are not codon specific and do not recognize codons, stimulate class 1 RF activity and confer GTP dependency upon the process. In prokaryotes, both class 1 RFs, RF1 and RF2, recognize UAA; however, UAG and UGA are decoded specifically by RF1 and RF2, respectively. In eukaryotes, eRF1, or ETF1, the functional counterpart of RF1 and RF2, functions as an omnipotent RF, decoding all 3 stop codons (Frolova et al., 1994 [PubMed 7990965]).[supplied by OMIM]
LocationChromosome: 5   Locus: 5q31.1
Gene position137878932 - 137841784  Map Viewer
Gene orientationminus
Gene size37149 bp
Gene sequence
OMIM ID600285