| Entrez gene ID | | 21355 |
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| Official gene symbol | | Tap2 |
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| Full name | | transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) |
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| Aliases | | ABC18,AI462429,APT2,Abcb3,Ham-2,Ham2,MTP2,PSF2,RING11,Tap-2,Y1,jas |
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| Gene summary | | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq] |
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| Location | | Chromosome: 17 Locus: 17 B1|17 18.62 cM |
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| Gene position | | 34341424 - 34353266 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 11843 bp |
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| Gene sequence |
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