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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for F3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2152
Official gene symbolF3
Full namecoagulation factor III (thromboplastin, tissue factor)
Aliases,CD142,FLJ17960,TF,TFA,
Gene summaryThis gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
LocationChromosome: 1   Locus: 1p22-p21
Gene position95007413 - 94994732  Map Viewer
Gene orientationminus
Gene size12682 bp
Gene sequence
OMIM ID134390