| Entrez gene ID | | 2155 |
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| Official gene symbol | | F7 |
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| Full name | | coagulation factor VII (serum prothrombin conversion accelerator) |
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| Aliases | | ,-, |
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| Gene summary | | This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. [provided by RefSeq] |
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| Location | | Chromosome: 13 Locus: 13q34 |
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| Gene position | | 113760105 - 113774995 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 14891 bp |
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| Gene sequence |
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