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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for F12 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 2161 Official gene symbol F12 Full name coagulation factor XII (Hageman factor) Aliases ,HAE3,HAEX,HAF, Gene summary This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq] Location Chromosome: 5   Locus: 5q33-qter Gene position 176836577 - 176829139  Map Viewer Gene orientation minus Gene size 7439 bp Gene sequence >F12:complement(21640412..21647850):Length=7439 CTATTGATCTGGACTCCTGGATAGGCAGCTGGACCAACGGACGGATGCCATGAGGGCTCT GCTGCTCCTGGGGTTCCTGCTGGTGAGCTTGGAGTCAACACTTTCGGTGAGTGCTGTGGG AACCAGGATTGTCCCAGGATTGTTCTGGGGGGTCGCTATCACAGCCATGAGCCATGGCCT CTGCTCATGACCTGTGGGTCCAGGTGACTAGGAGGCCTATGTGGAAAGGTGAGGCCAGCC CGGAAGGCCCAGGCAGAGGAGACAGACAACCAGACTGGGTGGATACAAGGGCACAGCCTG CATTTCTGGGGGAGATGGGCCTTAAGAAGACAACGGGGGGAGGTAGAAAGGGTTTGGGTC TTGGGAAGAAATCTCTGCATTTCTGGGCTGTGAGAGGAAGCTGCAGACTAGCAACAGATC GGTGGCAGGCTATGACTTATAGTCAGTTCCCTGCCTTCTTCTCTCCCTTGTAGATTCCAC CTTGGGAAGCCCCCAAGGAGCATAAGTACAAAGCTGAAGAGCACACAGTCGGTAAGTGGC CTGGCTCCTCCTCCCGGGAACCCTTGGGTGGGGATGTGTATGGTGCAGTGTGTGCAGTCT CAGGGCAGTCTAGTCTAGTGCCTACCTGGTGCTAGGTCTTATGCCCATGGGCACTAGAGT GATCGTGAGCTGTGTGATCCTTGAGGGCAGGGTATGGGCTGTGTCTAAGTGCCCACGAGC CTGGCTCGGAGCAGGTGCTTGAGATATGTGCTGCTGGCGCCATCACACCTGGGCTCCTGC CAGCCTTCCTCAGTTTCCCCAGCTTCTCCCCTTCTTTTCCTTTCCCCAGTACGTCTCATG GGCATCATTCATGCCACACAGAGGCCAGGGCCTTCAATGGGCAAGGAAGGATCAAGAGCT TGTCTCTGGCATCTGAATGCCTCTGAAGCCCAGCTTTATCACTTATGAGCTGGGTGACTC TGGGCGAGGGATTTGAGTTCTCCAAGCTTCAATTTCCCCTTCTGTGAAACCAGGTTGATA ACAGTAAACCTCTTAGGGTTGTTGAGAAGGGAAACCCATGTGAGGTATTCAGCCCATCAC CTGGTGCATGGAAATGCTTTACAAATATTAGCTTTTATTATGAAACTACCTTTTAGATGA AGGGTACCTGCCATTTCCCCCTTCCTCAAGCTCTGCCATAGCTCCCCATTGCTTTCATTC TTCCAGACACTAAATTACCTACATGCCAGGCATGGTGGCTCATGCCTGTAATCCCAGCAC TTTGGGAGGCCAAGGTCGGTGGATCATGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACA TGGTGAAATGCTGTCTCTACTAAAAGTACAAAAATTAGCCAGGCATGGTGGCATGCGCCA GTAGTCCCAGCTACTCGGGAGGCTGAGGCAGAAGAATTGCTTGAACCTGGGAGGTGAAGG TTGCAGTGAACGAAGATCACACCATTGCACTCCAGCTTGGGCAACACAGCAAGACTCCGT CTCAAAAAAAAAAAAAAAATTTACCTAGAGTGTGGCACATAGCAGGGCCTGTGAACCAGA TGGACCTTACCCTGGTGGGCCTGACTTGGTGGGGTTGAGTCTCTAAGCATGGCGTTGAGG CCCAGCACATTCCAACCCTGGACTCCCTCAGCCTCCTCTCTTCACCCCACACCCAAAAGT TTCTCCTCTCTCTTGCCTTACCCAAACTTGGTGCCCTATCCTTGCCTAATCCCCTGCCTA AGGTCCCCCTCCTCTCTGTCCGTCCATCCCATCTGCATCTTTTTTTTTTTTTGAGATGGA GTCTCGCTCTGTCCCCTAGGCTAGAGTGCAATGGCGCGATCTTGGCTCATTGCAACCTCC GCCTCCTGGGTTCAAGCGATTCTCTGCCTCAGCCTCCCGAGTTGCTGGGATTACAGGCAC ACAACTTCATGCTCAGCTAATTTTTGTATTTTTTAGTAGAGACAGGGTTTCACCATGTTG GCCAGGCTGGTCTCGAACTCCTGCCCTCAGGTGGTCCGCCCACCTTAGCCTCCCAAAGTG CTGGGATTACAGGCGTGAGCCACCGCGCCTGGCCCCCATTTGCATCTTAAAGGTCCATCT CAGATCCATTTCCATTTACTGTCCTAGTTCTGGTTTGGTCCTTGGCAAGTGCACTTTGCC TTGAACAAAATAGTGGCAAAAGCTTATTGAGCAGGTACTTTGTGCCAGACACTGCTCAGC ATTTCATGGCATTATCTCATGAAGCCCCACGACAATTCCTCTGAAGAAGACACAGGCAAT TCTCATTATTCGCGATGGTTATGTTCTATAAAATCACAGTGAACATTGAACTAGCAAACA GTATTAGGTTCCTGTGAGCCTCTGGTCACAACATTTTCATCAACCAACAGCATATAATCT GGTTTTATGTATGATTCTGTTTAAAGACATTTTATTTAGTATATGTGTTGCTGATTCATC AATGCTAAGCTGATGGCACTATAGCACACACCTGAATCAAGTGTCTAACACACGCTTTCT CCCTAAGGTAGCCTTCTTGTGCTTAGGAACTACACAGCTCTTCAGCAGGAGGCTCAGAGG CCATTTCCAAAAGCCAAATCCCCAGCAAAAGCACAAAGTGTGAAAAACGTTGCACTAAGT AGACTGAGAAGGACACTCATTCAATAGGAGAGCTGAAACAAGCAGCAGCAGCGTGACGCC TTGTTGAACCTTAACTGGGAATGTGCAAATTTTTCACTGCTCTGTGCATGCCCACAAATG GCCATGAAAACATTTCAAGTATTGACTTGGGAGTTACAAATAAAATTCAGCAAGTAGGCA CATTCTCAATGTAGAACCAGAGAAGAATGAGGATCAACTGTACTATTATTACTGCCGTTT TACAGATAAGGAAACCAAGGCTCAGATCAGAGTGGTTAACAGTGACTTCAACATTCAACA AGTATTATTAAGTGCCTACTTTGTGGCAAGTGCTCTTCCTGGCCTTGGGACTGAAGACTT ACCCAAGGTCACACAGCTAGCAGGTTGTGGAGTCAGGAGTCTACTCCAGCTATCTGACTC CTGAACCCAAGTTTTTTTTTTTTTCTTTAAGATGGAGTCTCACTCTGTCACCCAGGCTGG AGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTCCCGGGTTCACACCATTCTC CTGCCTCGGCCTCCCGAGTAGCTGGGACTACAGGCACCTGCCACCACCCCCAGCTAATTT TTTTGTATTTTTAGTAGAGAGGGGGTTTCACTGTATTAGCCAGGATGGTCTTGATCTCCT GACCTCGTGATCTGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCTTGAGCCACC GCGCCCGGCCCTGAACCCAACTTTTAGAGCAGAAAGTGTTTTCAATGCACAGCGACCTTT TTGAGGGTCTGTCCTTTTCCTGACCAGACCCTGAGGGACAGTGCCTGAGCAGTTGAGTAC AGGGGAAGTCCTCAGAGAGTGTGTTGTCCCTGCAGTTCTCACTGTCACCGGGGAGCCCTG CCACTTCCCCTTCCAGTACCACCGGCAGCTGTACCACAAATGTACCCACAAGGGCCGGCC AGGCCCTCAGCCCTGGTAAGACTACGCAGAGGAGTTGGAGCAGGGGCCTGGGAGACATGT ACCCTGCCTGTCCTTCTGTCCAAGGAACTCTGCTTGGAGAGAGGGGACTGTGATAGGGCA GGGTGGGCCAGGCCCCTGGGTAGAGCAGGGAAGCCTTGTCTCTTTCTACAGGTGTGCTAC CACCCCCAACTTTGATCAGGACCAGCGATGGGGATACTGTTTGGAGCCCAAGAAAGTGAA AGGTGCTACACACAGCCTCTGGGGTGGCCTGGGGCTCTCTCCTCCCGCCTCATTACTCTC CTGGTATCACCAGACCCCACACACCTGGGATTCTGGACCCAGCCCCTTCTCTCCCTCCAC AATACCCTTTGGAAGTCCAGAGGGAGAGTTCTGGGAAGGAGTGGTCCCATTTTGCAGGTG GGTAAACCAAGCTTGGAAACTTGGAGTAGCAAGGTCACAAGGCAAGTAGGTTCAAGAAGG GCCTTGGCCCCCAGCTGTGTGACTCAGCTCCCTGCTCTTCCTTCCACCATGTCCATCTCT CAGACCACTGCAGCAAACACAGCCCCTGCCAGAAAGGAGGGACCTGTGTGAACATGCCAA GCGGCCCCCACTGTCTCTGTCCACAACACCTCACTGGAAACCACTGCCAGAAAGGTGAGG AGATGTGGAGGACCTGGGCGGGGTGCTGGGGGACAGGGGCAACCCTGGGCCTACAGAATA GGTTGCTGGATACTCGGAGACTTGGCATGGTCCTAGACTCTCCTGAGACCACTATCCCTC TTTGTCCCCAGAGAAGTGCTTTGAGCCTCAGCTTCTCCGGTTTTTCCACAAGAATGAGAT ATGGTATAGAACTGAGCAAGCAGCTGTGGCCAGATGCCAGTGCAAGGGTCCTGATGCCCA CTGCCAGCGGCTGGCCAGCCAGGGTGAGCAGATGGTTGGGAACGGGCCAGGGAGGAGCGT CAGGAAGACAGGCTGGCAGGAGGCCGGGTGGTGTGCCAGGAAGGAGAGCTCTCTGGGGGG GTCTTTAGGCCCAGGGGTGGCTCACTGCGTTCCCTCCCCAAGCCTGCCGCACCAACCCGT GCCTCCATGGGGGTCGCTGCCTAGAGGTGGAGGGCCACCGCCTGTGCCACTGCCCGGTGG GCTACACCGGAGCCTTCTGCGACGTGGGTGAGTGAGGGTCTGGGGCAAGCAGAAGGCCAG CCCCCAGGTGGGACGGGCTTGCCAGGAAGGAGGAGGGAGAGTGCGGAAAGCAGATGAGAG GGAGGCAGGAGAGCCCAGCCTTGGCTGCCCAGGGAGCCCCCTTTCTCCTCAGACACCAAG GCAAGCTGCTATGATGGCCGCGGGCTCAGCTACCGCGGCCTGGCCAGGACCACGCTCTCG GGTGCGCCCTGTCAGCCGTGGGCCTCGGAGGCCACCTACCGGAACGTGACTGCCGAGCAA GCGCGGAACTGGGGACTGGGCGGCCACGCCTTCTGCCGGTGCGCCGCGTGGGGCTGGGTG ACCCCTCCGCCCCAGGGCTCCGGGCTCCCGGCGCTCTAACGGCGCCCCGTCGTGTGGCTA CAGGAACCCGGACAACGACATCCGCCCGTGGTGCTTCGTGCTGAACCGCGACCGGCTGAG CTGGGAGTACTGCGACCTGGCACAGTGCCAGACCCCAACCCAGGCGGCGCCTCCGACCCC GGTGTCCCCTAGGCTTCATGTCCCACTCATGCCCGCGCAGCCGGCACCGCCGAAGCCTCA GCCCACGACCCGGACCCCGCCTCAGTCCCAGACCCCGGGAGGTTAGGAAGTGGGGGGGGG AAGGAGGAGCCGAGAGGGCGCCGGGCGAGCTAGATTCCGGCCAGCCGGCCGCGGGCTCTC CGTCCTCAGCCCCTGCTCCTCCACAGCCTTGCCGGCGAAGCGGGAGCAGCCGCCTTCCCT GACCAGGAACGGCCCACTGAGCTGCGGGCAGCGGCTCCGCAAGAGTCTGTCTTCGATGAC CCGCGTCGTTGGCGGGCTGGTGGCGCTACGCGGGGCGCACCCCTACATCGCCGCGCTGTA CTGGGGCCACAGTTTCTGCGCCGGCAGCCTCATCGCCCCCTGCTGGGTGCTGACGGCCGC TCACTGCCTGCAGGACCGGCGAGTACCCGCCCGCCCAGAGCCGCCCCAGGGGCCGCGGCT CCTCCGTCTCCCAGCGCAGCTTCCACGCTGCACCCGAACCCGTGCCCTACCTTCTCCCGC CCCACCCTTCTTTCCACGCCCCTCCGGAGCTCCCGGGGAGGAAGCTGGAACACGGGATTG GGGTTCGGGAGCAGGGGGCTTCCCCAGAACGCTTGTGGCCAGGTCTGAGAGCGCTGCCTC TCCCCTACCCCCCCCGCAGGCCCGCACCCGAGGATCTGACGGTGGTGCTCGGCCAGGAAC GCCGTAACCACAGCTGTGAGCCGTGCCAGACGTTGGCCGTGCGCTCCTACCGCTTGCACG AGGCCTTCTCGCCCGTCAGCTACCAGCACGACCTGGGTGCGTGGGGGCGCCCCGCGGGGA CGGGAAGAGAGCTTGGGGCCCCGGCGTCCCCGCCTCACGCTCCTCTCCGCCCGGGTTAGC TCTGTTGCGCCTTCAGGAGGATGCGGACGGCAGCTGCGCGCTCCTGTCGCCTTACGTTCA GCCGGTGTGCCTGCCAAGCGGCGCCGCGCGACCCTCCGAGACCACGCTCTGCCAGGTGGC CGGCTGGGGCCACCAGTTCGAGGGTAGGCACAACTGCTAGGGGCAGGGGTAGGGGAGGAG ACCTTTGATCACTGGGTTAGGCGGAAGAAGCCCGCGACTTTGGTATCGTTCCGGGTGCCT ACAGAATGGGTGGCGCTGACCTGATGGGTTGTGAGAATGTGTAGGTGAATCCCAGGTAGA ATCCCAGGGCCTGGGATTCACTGCTGGGATCCCCAAATCTCCTGGGGATACAGGGAGAAT CGAACTTGCTCTTGGTTCCCTCTGGGCGCCGGGCTGCAAAGGCCAACTAGGACGCTGGCC CCGCGCTCCGGGCTAGTGTGGGAGCCAGGTTCTGCGACTCTGGATGGGTGGTGGGGGAGG GGTTTCTGTTTCCGCTCCGCCCATTCAAATCCTGGCTTTTCTCTGGACCTCAGCCTCCTT GCCTATGAAATTGAATTAATGGCACCTCCTCCCCTTCGGGCTTGCTGCGAGAGAGGAAGG GCATGAGTGGGTTTACAAGCGCCTGGAGCAGCTTTGTCCATCGTCCGGGCGGCAAGCGTT GTCAGATGGGGTGTGAAGAAGGCGCTCTGTGTTCGCAGGGGCGGAGGAATATGCCAGCTT CCTGCAGGAGGCGCAGGTACCGTTCCTCTCCCTGGAGCGCTGCTCAGCCCCGGACGTGCA CGGATCCTCCATCCTCCCCGGCATGCTCTGCGCAGGGTTCCTCGAGGGCGGCACCGATGC GTGCCAGGTGAGCTCTTAGCCCGGTTGGCGCCCTTCCCCGAGGCCGTCAGGCACAAATCT CAGGTCCACAGCGCTGAGCTGCGTGTTTCCGACCCAGGGTGATTCCGGAGGCCCGCTGGT GTGTGAGGACCAAGCTGCAGAGCGCCGGCTCACCCTGCAAGGCATCATCAGCTGGGGATC GGGCTGTGGTGACCGCAACAAGCCAGGCGTCTACACCGATGTGGCCTACTACCTGGCCTG GATCCGGGAGCACACCGTTTCCTGATTGCTCAGGGACTCATCTTTCCCTCCTTGGTGATT CCGCAGTGAGAGAGTGGCTGGGGCATGGAAGGCAAGATTGTGTCCCATTCCCCCAGTGCG GCCAGCTCCGCGCCAGGATGGCGCAGGAACTCAATAAAGTGCTTTGAAAATGCTGAGAA OMIM ID 610619