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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ALDH2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID217
Official gene symbolALDH2
Full namealdehyde dehydrogenase 2 family (mitochondrial)
Aliases,ALDH-E2,ALDHI,ALDM,MGC1806,
Gene summaryThis protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q24.2
Gene position112204346 - 112247784  Map Viewer
Gene orientationplus
Gene size43439 bp
Gene sequence
OMIM ID100650