Entrez gene ID | | 219927 |
Official gene symbol | | MRPL21 |
Full name | | mitochondrial ribosomal protein L21 |
Aliases | | ,L21mt,MGC62013,MRP-L21, |
Gene summary | | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q13.3 |
Gene position | | 68671303 - 68658746 Map Viewer |
Gene orientation | | minus |
Gene size | | 12558 bp |
Gene sequence |
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OMIM ID | | 611834 |
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