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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for Trp63 (Mus musculus)
(Information is obtained from NCBI Gene database)
Entrez gene ID22061
Official gene symbolTrp63
Full nametransformation related protein 63
AliasesAI462811,Ket,MGC115972,P51/P63,P63,P73l,Tp63,Trp53rp1
Gene summaryThis gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.
LocationChromosome: 16   Locus: 16 B1|16 19.3 cM
Gene position25683851 - 25892174  Map Viewer
Gene orientationplus
Gene size208324 bp
Gene sequence