Entrez gene ID | | 22431 |
Official gene symbol | | Wt1 |
Full name | | Wilms tumor 1 homolog |
Aliases | | D630046I19Rik,Wt-1 |
Gene summary | | This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It plays an essential role in the normal development of the urogenital system, and the orthologous human gene is mutated in a small subset of patients with Wilm's tumors. Alternative splicing has been noted for this gene, however, the full-length nature of these variants is not known. The mRNA for this gene has been shown to initiate translation from non-AUG (CUG) and AUG translation start sites, resulting in different isoforms. This gene has also been reported to be imprinted, with preferential expression from the maternal allele. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2 E|2 58.0 cM |
Gene position | | 104966686 - 105013771 Map Viewer |
Gene orientation | | plus |
Gene size | | 47086 bp |
Gene sequence |
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