Entrez gene ID | | 2268 |
Official gene symbol | | FGR |
Full name | | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog |
Aliases | | ,FLJ43153,MGC75096,SRC2,c-fgr,c-src2,p55-Fgr,p55c-fgr,p58c-fgr, |
Gene summary | | This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p36.2-p36.1 |
Gene position | | 27961727 - 27938800 Map Viewer |
Gene orientation | | minus |
Gene size | | 22928 bp |
Gene sequence |
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OMIM ID | | 164940 |
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