Entrez gene ID | | 22806 |
Official gene symbol | | IKZF3 |
Full name | | IKAROS family zinc finger 3 (Aiolos) |
Aliases | | ,AIO,AIOLOS,ZNFN1A3, |
Gene summary | | This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q21 |
Gene position | | 38020441 - 37921198 Map Viewer |
Gene orientation | | minus |
Gene size | | 99244 bp |
Gene sequence |
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OMIM ID | | 606221 |
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