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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PPM1E (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID22843
Official gene symbolPPM1E
Full nameprotein phosphatase, Mg2+/Mn2+ dependent, 1E
Aliases,CaMKP-N,DKFZp781F1422,KIAA1072,POPX1,PP2CH,
Gene summaryThe protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42). [provided by RefSeq]
LocationChromosome: 17   Locus: 17q22
Gene position56833232 - 57062537  Map Viewer
Gene orientationplus
Gene size229306 bp
Gene sequence