Entrez gene ID | | 22848 |
Official gene symbol | | AAK1 |
Full name | | AP2 associated kinase 1 |
Aliases | | ,DKFZp686F03202,DKFZp686K16132,FLJ23712,FLJ25931,FLJ31060,FLJ42882,FLJ45252,KIAA1048,MGC138170,MGC164568,MGC164570, |
Gene summary | | Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2p14 |
Gene position | | 69870977 - 69685127 Map Viewer |
Gene orientation | | minus |
Gene size | | 185851 bp |
Gene sequence |
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