Entrez gene ID | | 2287 |
Official gene symbol | | FKBP3 |
Full name | | FK506 binding protein 3, 25kDa |
Aliases | | ,FKBP-25,PPIase, |
Gene summary | | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q21.2 |
Gene position | | 45603732 - 45584802 Map Viewer |
Gene orientation | | minus |
Gene size | | 18931 bp |
Gene sequence |
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OMIM ID | | 186947 |
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