Entrez gene ID | | 22992 |
Official gene symbol | | KDM2A |
Full name | | lysine (K)-specific demethylase 2A |
Aliases | | ,CXXC8,DKFZp434M1735,FBL11,FBL7,FBXL11,FLJ00115,FLJ46431,JHDM1A,KIAA1004,LILINA,SF-KDM2A, |
Gene summary | | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 6 highly degenerated leucine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q13.2 |
Gene position | | 66886740 - 67025553 Map Viewer |
Gene orientation | | plus |
Gene size | | 138814 bp |
Gene sequence |
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OMIM ID | | 605657 |
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