Entrez gene ID | | 23002 |
Official gene symbol | | DAAM1 |
Full name | | dishevelled associated activator of morphogenesis 1 |
Aliases | | ,FLJ41657,KIAA0666, |
Gene summary | | Functions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q23.1 |
Gene position | | 59655399 - 59836471 Map Viewer |
Gene orientation | | plus |
Gene size | | 181073 bp |
Gene sequence |
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OMIM ID | | 606626 |
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