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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DAAM1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID23002
Official gene symbolDAAM1
Full namedishevelled associated activator of morphogenesis 1
Aliases,FLJ41657,KIAA0666,
Gene summaryFunctions of the cell cortex, including motility, adhesion, and cytokinesis, are mediated by the reorganization of the actin cytoskeleton and recent evidence suggests a role for the Formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture, to control cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined. [provided by RefSeq]
LocationChromosome: 14   Locus: 14q23.1
Gene position59655399 - 59836471  Map Viewer
Gene orientationplus
Gene size181073 bp
Gene sequence
OMIM ID606626