Entrez gene ID | | 23089 |
Official gene symbol | | PEG10 |
Full name | | paternally expressed 10 |
Aliases | | ,EDR,HB-1,KIAA1051,MEF3L,Mar2,Mart2,RGAG3, |
Gene summary | | This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q21 |
Gene position | | 94285637 - 94299007 Map Viewer |
Gene orientation | | plus |
Gene size | | 13371 bp |
Gene sequence |
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OMIM ID | | 609810 |
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