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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NFASC (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID23114
Official gene symbolNFASC
Full nameneurofascin homolog (chicken)
Aliases,DKFZp686P2250,FLJ46866,KIAA0756,NF,NRCAML,
Gene summaryThis gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
LocationChromosome: 1   Locus: 1q32.1
Gene position204797782 - 204991950  Map Viewer
Gene orientationplus
Gene size194169 bp
Gene sequence
OMIM ID609145