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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FLG (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID2312
Official gene symbolFLG
Full namefilaggrin
Aliases,ATOD2,
Gene summaryThe protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
LocationChromosome: 1   Locus: 1q21.3
Gene position152297679 - 152274651  Map Viewer
Gene orientationminus
Gene size23029 bp
Gene sequence
OMIM ID135940