Entrez gene ID | | 23291 |
Official gene symbol | | FBXW11 |
Full name | | F-box and WD repeat domain containing 11 |
Aliases | | ,BTRC2,BTRCP2,FBW1B,FBXW1B,Fbw11,Hos,KIAA0696, |
Gene summary | | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q35.1 |
Gene position | | 171433877 - 171288556 Map Viewer |
Gene orientation | | minus |
Gene size | | 145322 bp |
Gene sequence |
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OMIM ID | | 605651 |
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