Entrez gene ID | | 23370 |
Official gene symbol | | ARHGEF18 |
Full name | | Rho/Rac guanine nucleotide exchange factor (GEF) 18 |
Aliases | | ,KIAA0521,MGC15913,P114-RhoGEF, |
Gene summary | | Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19p13.3 |
Gene position | | 7459999 - 7537371 Map Viewer |
Gene orientation | | plus |
Gene size | | 77373 bp |
Gene sequence |
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