Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CBX5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID23468
Official gene symbolCBX5
Full namechromobox homolog 5 (HP1 alpha homolog, Drosophila)
Aliases,HP1,HP1A,
Gene summaryThis gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q13.13
Gene position54673915 - 54624730  Map Viewer
Gene orientationminus
Gene size49186 bp
Gene sequence
OMIM ID604478