Entrez gene ID | | 23468 |
Official gene symbol | | CBX5 |
Full name | | chromobox homolog 5 (HP1 alpha homolog, Drosophila) |
Aliases | | ,HP1,HP1A, |
Gene summary | | This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q13.13 |
Gene position | | 54673915 - 54624730 Map Viewer |
Gene orientation | | minus |
Gene size | | 49186 bp |
Gene sequence |
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OMIM ID | | 604478 |
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