Entrez gene ID | | 23475 |
Official gene symbol | | QPRT |
Full name | | quinolinate phosphoribosyltransferase |
Aliases | | ,QPRTase, |
Gene summary | | This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16p11.2 |
Gene position | | 29690441 - 29709315 Map Viewer |
Gene orientation | | plus |
Gene size | | 18875 bp |
Gene sequence |
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OMIM ID | | 606248 |
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