Entrez gene ID | | 23499 |
Official gene symbol | | MACF1 |
Full name | | microtubule-actin crosslinking factor 1 |
Aliases | | ,ABP620,ACF7,FLJ45612,FLJ46776,KIAA0465,KIAA1251,MACF,OFC4, |
Gene summary | | The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p32-p31 |
Gene position | | 39547118 - 39952789 Map Viewer |
Gene orientation | | plus |
Gene size | | 405672 bp |
Gene sequence |
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OMIM ID | | 608271 |
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