Entrez gene ID | | 2356 |
Official gene symbol | | FPGS |
Full name | | folylpolyglutamate synthase |
Aliases | | ,-, |
Gene summary | | This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9q34.1 |
Gene position | | 130565154 - 130576556 Map Viewer |
Gene orientation | | plus |
Gene size | | 11403 bp |
Gene sequence |
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