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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ARHGAP8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID23779
Official gene symbolARHGAP8
Full nameRho GTPase activating protein 8
Aliases,BPGAP1,FLJ20185,PP610,
Gene summaryThis gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq]
LocationChromosome: 22   Locus: 22q13.31
Gene position45148438 - 45258664  Map Viewer
Gene orientationplus
Gene size110227 bp
Gene sequence
OMIM ID609405