Entrez gene ID | | 23779 |
Official gene symbol | | ARHGAP8 |
Full name | | Rho GTPase activating protein 8 |
Aliases | | ,BPGAP1,FLJ20185,PP610, |
Gene summary | | This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene. [provided by RefSeq] |
Location | | Chromosome: 22 Locus: 22q13.31 |
Gene position | | 45148438 - 45258664 Map Viewer |
Gene orientation | | plus |
Gene size | | 110227 bp |
Gene sequence |
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OMIM ID | | 609405 |
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