Entrez gene ID | | 238055 |
Official gene symbol | | Apob |
Full name | | apolipoprotein B |
Aliases | | AI315052,MGC176318,apob-100,apob-48 |
Gene summary | | This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the mouse apoB-48 isoform is also found in mouse liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2179 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12 A1.1 |
Gene position | | 7984483 - 8023645 Map Viewer |
Gene orientation | | plus |
Gene size | | 39163 bp |
Gene sequence |
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