Entrez gene ID | | 23961 |
Official gene symbol | | Oas1b |
Full name | | 2'-5' oligoadenylate synthetase 1B |
Aliases | | Flv,L1,Mmu-L1,Oas1,Oias-2,Oias2,Wnv |
Gene summary | | This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5 F|5 67.0 cM |
Gene position | | 121262644 - 121274172 Map Viewer |
Gene orientation | | plus |
Gene size | | 11529 bp |
Gene sequence |
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