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Gene information for Oas1b (Mus musculus)
(Information is obtained from NCBI Gene database)
Entrez gene ID23961
Official gene symbolOas1b
Full name2'-5' oligoadenylate synthetase 1B
AliasesFlv,L1,Mmu-L1,Oas1,Oias-2,Oias2,Wnv
Gene summaryThis gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq]
LocationChromosome: 5   Locus: 5 F|5 67.0 cM
Gene position121262644 - 121274172  Map Viewer
Gene orientationplus
Gene size11529 bp
Gene sequence