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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ALOX5 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID240
Official gene symbolALOX5
Full namearachidonate 5-lipoxygenase
Aliases,5-LO,5-LOX,5LPG,LOG5,MGC163204,
Gene summaryThis gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q11.2
Gene position45869629 - 45941565  Map Viewer
Gene orientationplus
Gene size71937 bp
Gene sequence
OMIM ID152390