Entrez gene ID | | 241 |
Official gene symbol | | ALOX5AP |
Full name | | arachidonate 5-lipoxygenase-activating protein |
Aliases | | ,FLAP, |
Gene summary | | This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. [provided by RefSeq] |
Location | | Chromosome: 13 Locus: 13q12 |
Gene position | | 31309669 - 31338556 Map Viewer |
Gene orientation | | plus |
Gene size | | 28888 bp |
Gene sequence |
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OMIM ID | | 603700 |
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