| Entrez gene ID | | 25430 |
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| Official gene symbol | | Dio1 |
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| Full name | | deiodinase, iodothyronine, type I |
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| Aliases | | 5DI,ITDI1,MGC93462,TXDI1 |
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| Gene summary | | The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). This protein contains a selenocysteine (Sec) residue, which is necessary for maximal enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Conversion of T4 to T3 is impaired in experimental selenium deficiency, suggesting an essential role for this trace element in thyroid hormone action. [provided by RefSeq] |
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| Location | | Chromosome: 5 Locus: 5q34 |
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| Gene position | | 128385701 - 128404014 Map Viewer |
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| Gene orientation | | minus |
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| Gene size | | 18314 bp |
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| Gene sequence |
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