Entrez gene ID | | 2550 |
Official gene symbol | | GABBR1 |
Full name | | gamma-aminobutyric acid (GABA) B receptor, 1 |
Aliases | | ,FLJ92613,GABABR1,GABBR1-3,GB1,GPRC3A,dJ271M21.1.1,dJ271M21.1.2, |
Gene summary | | Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq] |
Location | | Chromosome: 6 Locus: 6p21.31 |
Gene position | | 29600962 - 29570005 Map Viewer |
Gene orientation | | minus |
Gene size | | 30958 bp |
Gene sequence |
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OMIM ID | | 603540 |
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